| 赵文辉 张清媛 康欣梅.MMP - 9、VEGF、bFGF 在非何杰金淋巴瘤的表达及临床意义[J].,2006,6(7):17-19 |
| MMP - 9、VEGF、bFGF 在非何杰金淋巴瘤的表达及临床意义 |
| Expression and Significance of MMP- 9, VEGF and bFGF in non- Hodgkin. s lymphoma |
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| DOI： |
| 中文关键词: MMP - 9 VEGF bFGF 非何杰金淋巴瘤 |
| 英文关键词: MMP- 9 VEGF bFGF Non- Hodgkin. s lymphoma |
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| 中文摘要: |
| 目的: 探讨MMP- 9、VEGF、bFGF 在非何杰金淋巴瘤(NHL ) 中的表达及意义。方法: 免疫组化法。结果MMP - 9、
VEGF、bFGF 在NHL 中表达率分别为43. 66%、33. 80%、25. 35%, 均高于正常淋巴结组织中的表达, 差异均有显著性( Pm = 0.
0023, Pv= 0. 001, Pb= 0. 0049) 。组5 年生存率明显低于MMP - 9 (- ) 组(P = 0. 008) 。VEGF 在T 细胞型中表达率高于B 细胞
型(P = 0. 019) , VEGF 阳性组治疗缓解率低( P = 0. 045) 。巨块型NHL 中bFGF 表达率较高( P = 0. 028) , bFGF( + ) 组5 年生存率
明显低于bFGF( - ) 组( P = 0. 041) 。MMP - 9、VEGF、bFGF 之间无协同表达。结论: MMP - 9、VEGF、bFGF 在NHL 中的表达高于
正常淋巴组织, 可能与淋巴组织恶变有关。MMP - 9、bFGF 均与生存期呈负相关, 是NHL 预后差的指标, 联合检测更有助于判断
预后。VEGF 阳性组治疗效果差, 提示VEGF 阳性NHL 患者加用VEGF 靶向治疗可能会提高疗效。 |
| 英文摘要: |
| Objective: To investigate the expression and clinical significance of Matrix Matalloproteinase 9, Vascular Endothelial
Growth Factor and basic Fibroblast Growth Factor in non- Hodgkin. s lymphoma. Methods: The expression of MMP- 9, VEGF and bFGF were
evaluated in 71 cases of non- Hodgkin. s lymphoma by means of immunohistochemistry. Results: The expression of MMP- 9, VEGF and bFGF
were detected in non- Hodgkin. s lymphoma and the expression rates were 43. 66%, 33. 80%, 25. 35% respectively. The 5- year survival rate
of patients withMMP- 9 ( + ) is lower( P= 0. 008) . The positive rate of VEGF expression in T cell type was higher than in B cell type( P= 0.
019) . The complete and partial response rates were significantly higher in VEGF - negative group than in the VEGF - positive group( P= 0.
045) . The expression of bFGF was related with bulky tumor and overal survival. The positive rate of bFGF in non- bulky tumor was lower than
in bulky tumor( P= 0. 028) . Overal survival was lower in bFGF - positive group than in bFGF- negative group( P= 0. 041) . There was no relationship
among the expression of VEGF, bFGF andMMP- 9. Conclution: As well as in many other solid tumors, we detected the expression of
MMP- 9, VEGF and bFGF in non- Hodgkin. s lymphoma( NHL) . MMP- 9 and bFGF were related with overal survical and may be marks of unfavorable
prognosis in non- Hodgkin. s lymphoma. VEGF could serve as a predictor of poor response to chemotherapy, so the combination of
VEGF target drug and chemotherapy may benefit VEGF- positive patient. |
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