| 张晶1 张浩1，2 曾晓锋1 王尚文1 赵永和1 李桢1.甲基苯丙胺中毒mG1uR5 的表达[J].,2011,11(1):44-47 |
| 甲基苯丙胺中毒mG1uR5 的表达 |
| Altered Expression of Metabolic Glutamate Receptor 5 inMethamphetamine Intoxication in the Rats |
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| DOI： |
| 中文关键词: 甲基苯丙胺 中毒 mG1uR5 |
| 英文关键词: Methamphetamine Intoxication MG1uR5 |
| 基金项目:国家自然科学基金项目(NO30660202);教育部春晖项目（NOZ2006-1-65003）;云南省科技厅项目（NO2006GH22） |
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| 中文摘要: |
| 目的：研究代谢性谷氨酸受体5（mG1uR5）在甲基苯丙胺中毒的损伤机制中的作用。方法：设立实验组，对照组。实验组分别
给予20 mg/kg，10 mg/kg 腹腔注射MA；对照组分别给予同剂量的生理盐水。末次注射后24 h 内腹腔注射戊巴比妥钠麻醉大鼠后
用4%多聚甲醛灌注、取脑后行代谢性谷氨酸受体5 的免疫组织化学染色，观察并计数mG1uR5 在不同脑区的表达。结果：实验组
mG1uR5 在大脑纹状体、海马的表达较对照组显著增强，差异有显著性（P<0.05），并呈剂量依赖性。结论：mG1uR5 参与了甲基苯
丙胺中毒的损伤机制。 |
| 英文摘要: |
| Objective: To investigate the effect of mG1uR5 receptors on methamphetamine hydrochloride in the rats. Methods
Forty male Wistar rats were randomly divided into control group (n=20) and experimental group (n=20). Rats in EG were peritoneal injection
with methamphetamine hydrochloride (20 mg/kg-HDG, 10 mg/kg-MDG, bid). CG was administered with the same normal saline.
Within 24 h of the last methamphetamine injection, rats were anesthetized by intraperitoneal injection of pentobarbital sodium and then
were perfused by 4 % paraformaldehyde. After the removement of brain ,mGluR5 by immunohistochemical staining were observed and
counted in different brain areas. Results: The expression of mG1uR5 in the hippocampus and the striatum of the brain for experimental
group was enhanced markedly compared with control group (P<0.05) and it had dose dependent. Conclusion: MG1uR5 participated in
the damage mechanism of methamphetamine poisoning. |
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