| 徐威威1 杨彦华2 纪萍2 韦孝铭2 于建宪2.心脏性猝死者心肌HO-1 和VEGF 的表达及意义[J].,2011,11(6):1114-1117 |
| 心脏性猝死者心肌HO-1 和VEGF 的表达及意义 |
| Expressions of HO-1 and VEGF in Patients of Sudden Cardiac Death |
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| DOI： |
| 中文关键词: 心性猝死 血红素加氧酶-1 血管内皮生长因子 免疫组织化学 |
| 英文关键词: Sudden cardiac death HO-1 VEGF Immunohistochemistry |
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| 中文摘要: |
| 目的：探讨血红素加氧酶-1（heme oxygenase-1，HO-1）、血管内皮生长因子(vascular endothelial growth factor ,VEGF)在心脏
性猝死病人心室肌细胞中的表达及其意义。方法：运用免疫组织化学方法和Simple PCI 图像分析系统观察33 例心脏性猝死组和
18 例非心脏性猝死对照组尸检心肌组织中HO-1、VEGF 蛋白的表达情况。结果：心脏性猝死组心肌组织HO-1( 155.090±8.957 )
和VEGF 蛋白表达(121.020±10.927)均显著高于非心脏性猝死对照组(116.200±6.355 、84.207±4.402 ，均p<0.05）。结论：HO-1
和VEGF 蛋白在心脏性猝死者心肌组织表达增强，可能与心脏性猝死有一定关系。 |
| 英文摘要: |
| Objective: To investigate expression of the heme oxygenase-1 ( HO-1）and vascular endothelial growth factor (VEGF)
in the left ventricle in patients with sudden cardiac death (SCD). Methods: Immunohistochemistry and Simple PCI image analysis system
were used to detect the expressions of HO-1 and VEGF in 33 cases of SCD and 18 cases of non SCD (control group). Results: The expressions
of HO-1( 155.090±8.957) and VEGF(121.020±10.927) in the myocardium of patients in SCD group were significantly higher
than those in control group (116.200±6.355, 84.207±4.402 ,all p<0.05）. Conclusions: The high expression of HO-1 and VEGF may be
related with the sudden cardiac death to some extent. |
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