| 吴政海洪文瑶管宏新郑学胜王旭辉李心远李世亭.家兔迟发性面瘫模型建立及药物干预研究[J].,2011,11(11):2113-2116 |
| 家兔迟发性面瘫模型建立及药物干预研究 |
| Rabbit Model of Delayed Facial Paralysis and Drug Intervention |
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| DOI： |
| 中文关键词: 迟发性面瘫 模型 药物防治 |
| 英文关键词: Delayed facial paralysis Model Drug prevention and treatment |
| 基金项目:上海市科委基金（074119630） |
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| 中文摘要: |
| 目的：优化迟发性面瘫的建模方法，并对药物的神经保护作用进行观察。方法：家兔48 只共96 侧面神经，分A、B、C、D 4 个
实验组，以一侧面神经进行实验处理，另一侧为自身对照。A 组：直视下钳夹损伤桥池段面神经；B 组：直视下向桥小脑角注射动
脉血，以诱导血管痉挛；C 组：处理因素=A 组+B 组；D 组：在C 组基础上，应用药物（强的松+ 丹参+ 维生素B1+ 维生素B12）干
预。观察家兔面瘫，并做面神经病理切片，比较各组间迟发性面瘫发生率、面瘫持续时间及预后。结果：面瘫发生情况：A 组6 只家
兔(6/11，54.5%)出现迟发性面瘫；平均面瘫持续时间为13.2 天。B 组有2 只(2/12，16.7%)出现迟发性面瘫，平均持续8 天。C 组6
只(6/12，50%)家兔出现迟发性面瘫，平均持续14.3 天。D 组4 只(4/12，33.33 %)出现迟发性面瘫，平均持续6 天。所有自身对照侧
均无面瘫发生。病理：各组均见神经纤维水肿；A、C 两组呈高度水肿改变，神经束周围结构紊乱；B 组见神经内血管细小，而水肿
较A、C 两组轻微；D 组呈轻度水肿改变。结论：C 组出现迟发性面瘫几率高，是较好的模型；联合应用强的松、丹参、维生素B1、维
生素B12 虽不能防止迟发性面瘫发生，但可使迟发性面瘫病程明显缩短。 |
| 英文摘要: |
| ABSTRACTObjective:Optimization ofmodeling of delayed facial paralysis.The neuroprotective effect of several drugswere observed.
Methods: Forty-eight rabbits were assigned to A, B, C, D 4 experimental groups, with one side of the facial nerve to the experimental
treatment, and the other side of self-control. A: The cisternal section of the facial nerve was injured by clamp. B: Injection of arterial
blood to the cerebellopontine angle to induce vasospasm. C: treatment factor = group A + group B. D group: C group plus the application
of drug (prednisone + SM + vitamin B1 + vitamin B12) intervention. The rabbit facial paralysis was observed. And facial nerve biopsy
was done. The incidence of delayed facial paralysis, duration and prognosis were compared. Results: The incidence of facial paralysis: in
group A 6 rabbits (6 / 11, 54.5%) had delayed facial paralysis; the average duration of facial paralysis was 13.2 days. In group B, 2 (2 /
12, 16.7%) had delayed facial paralysis, the average duration was 8 days. In group C 6 (6 / 12, 50%) had delayed facial paralysis, and the
average duration was 14.3 days. In group D 4 (4 / 12, 33.33%) had delayed facial paralysis, the average duration was 6 days. There was
no facial paralysis in all self-control sides. Pathology: Nerve fiber edema was seen in each group ; groups A, C showed a high degree of
edema, with nerve bundles around the structural disorder; group B showed small blood vessels within the nerve, and mild edema compared
with groups A, C; group D showed a slight edema change. Conclusion: Group C had higher risk of delayed facial paralysis, so it is
a better model. Combination of prednisone, Salvia, vitamin B1, vitamin B12, although not able to prevent the occurrence of delayed facial
paralysis, but the duration of the delayed facial paralysis was significantly shortened. |
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