| 李斌胡善友吴晓许惠利张华明王莉.血脂康胶囊对冠心病患者的抗氧化及抗炎效果研究[J].,2011,11(12):2289-2291 |
| 血脂康胶囊对冠心病患者的抗氧化及抗炎效果研究 |
| Anti-oxidant and Anti-inflammatory Effects of Xuezhikang Capsule onPatients with Coronary Heart Diseases |
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| DOI： |
| 中文关键词: 血脂康胶囊 冠心病；抗氧化；抗炎 |
| 英文关键词: Capsule Xuezhikang Coronary heart diseases Anti-oxidant Anti-inflammatory |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨血脂康胶囊对冠心病患者的抗氧化及抗炎效果和意义。方法：选取冠心病并且有一定程度的脂代谢紊乱的患者
64 例，按随机对照原则随机分为A 组（32 例）及B 组（32 例），A 组给予血脂康胶囊600mg，日2 次；B 组予洛伐他汀40mg／d，丙
氨酸转氨酶或天冬氨酸转氨酶升高超过正常值3 倍以上的患者服用剂量减半，即洛伐他汀20mg／d，经治疗或者观察恢复正常
后再加到40mg／d。共比8 周，检测实验前后的血浆ALT，AST，CK，OX－LDL，CRP 及SOD 水平。结果：血脂康胶囊可以明显
的降低血浆TG，CHOL,LDL 水平，并且与对照组差异有显著性意义（P＜0.05）。血脂康胶囊可以明显的降低血浆OX－LD，CRP
水平，与对照组差异有非常显著性意义（P＜0.01），血脂康胶囊可以提高血浆SOD 水平优于对照组（P＜0.01），而升高ALT，AST，
CK 的副作用较对照组低（P＜0.05）。结论：血脂康胶囊常规剂量不仅有效调脂而安全，并且有一定的抗氧化及抗炎效果。 |
| 英文摘要: |
| Objective: To study the Capsule Xuezhikang effect to coronary heart diseases about anti-oxidant and antiinflammatory.
Methods: 64 cases with coronary heart disease and lipid disorders are randomized into two groups:group A (32 cases) and
group B (32 cases), while the group A take Capsule Xuezhikang with the dose is 600mg，BID for 8 weeks. The group B take lovastatin
with the dose is 40mg qd . To detect and analysis the level of plasma ALT，AST，CK，OX－LDL，CRP and SOD. Results: Capsule
Xuezhikang can decrease the level of plasma TG，CHOL and LDLwhich is better than the control （P＜0.05）; and it can also decrease
the level of plasma OX－LD and CRP which is better than the control（P＜0.01）; The level of plasma SOD in group A is higher than that
of group B（P＜0.01）;The group A has lesser side effect on increasing the level of plasma ALT，AST and CK than that of group B（P＜
0.05）.Conclusion: Capsule Xuezhikang can not only effectivly regulate the level of plasma lipoid，it can also against oxidant and
inflammatory. |
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