| 王桂锋1 王晓红1 尹国武1 朱晓明1 姚元庆2.miR-19a 在正常妊娠及重度子痫前期患者胎盘中的表达[J].,2011,11(12):2335-2337 |
| miR-19a 在正常妊娠及重度子痫前期患者胎盘中的表达 |
| Expression of MiR-19a in Placentas From Women withPreeclampsia and Normal Pregnancy |
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| DOI： |
| 中文关键词: 子痫前期 微小RNA 胎盘 |
| 英文关键词: Preeclampsia MiRNA Placenta |
| 基金项目:国家“973”项目基金（2007CB948102）资助 |
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| 中文摘要: |
| 目的：通过检测正常妊娠及重度子痫前期患者胎盘组织中miR-19a 的表达, 探讨其与子痫前期发病的关系。方法：收集10
例重度子痫前期患者胎盘组织(实验组)和10 例正常产妇胎盘组织（对照组）,应用荧光实时定量PCR (Real Time PCR)的方法检测
两组miR-19a 的表达差异。结果：重度子痫前期患者胎盘组织中miR-19a 表达升高（P<0.05）。结论：子痫前期患者胎盘组织中存
在差异表达的miRNA，miR-19a 在胎盘组织中的高表达可能与子痫前期的发病有关。 |
| 英文摘要: |
| Objective: To study the relationship of the pathogenesis of preeclampsia with miR-19a by measuring the expression of
miR-19a in normal pregnancy and preeclampsia placenta. Methods: 10 cases of severe preeclampsia (experimental group) and 10 normal
placenta maternal placenta (control) were collected, fluorescent Real-Time quantitative PCR method was used to detect the expression of
miR-19a in two different groups. Results: miR-19a expression in patients with severe preeclampsia placenta increased significantly
comparing with those in normal placenta. Conclusion: miR-19a expression increased significantly in preeclampsia placenta, and there
exist an connection between high expression of miR-19a and the pathogenesis of preeclampsia. |
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