| 熊元元1,2 李有秋1△ 彭耀金1.阿尔茨海默病与雌激素和褪黑素的相关性研究进展[J].,2011,11(12):2376-2380 |
| 阿尔茨海默病与雌激素和褪黑素的相关性研究进展 |
| Correlation of Alzheimer's Disease to Estrogen and Melatonin |
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| DOI： |
| 中文关键词: 阿尔茨海默病 雌激素 褪黑素 |
| 英文关键词: Alzheimer's disease Estrogen Melatomin |
| 基金项目:湖南省教育厅科学研究项目（09C632） |
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| 中文摘要: |
| 阿尔茨海默病（AD）是引起痴呆的第一病因，其发病机制尚不十分明确。目前尚无特效的药物可逆转脑功能缺损或阻止病
情进展，临床上用胆碱乙酰转移酶抑制剂、抗精神症状药物、维生素E 等均只能轻微改善症状。雌激素和褪黑素在基础和临床研
究中都显示对AD 有治疗作用，且二者的疗效与AD 的病程有明显相关性。 |
| 英文摘要: |
| Alzheimer's disease is the top etiology of dementia,whose pathogenesis is not clear yet.So far ,there is no effective
drugs to reverse the defect in brain function or prevent its progression.Drugs used in clinical practice nowadays such as the choline
acetyltransferase inhibitor,anti-psychotic symptoms of drugs, vitamin E can do only modest improvement in symptoms. Melatomin and
estrogen are proved to be useful for AD both in basic and clinical studies and their efficacy both related to the duration of AD.In this
paper, estrogen and melatonin for the treatment of AD are reviewed. |
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