| 巨文锋1 薛莹1 路美玲1 张萌斌1 李建宁1，2.改良CCI 大鼠痛行为学检测与损伤区自发放电活动再观察[J].,2011,11(14):2632-2634 |
| 改良CCI 大鼠痛行为学检测与损伤区自发放电活动再观察 |
| Pain Behaviour and Ectopic Spontaneous Discharge in Modified ChronicConstriction Injury Rats |
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| DOI： |
| 中文关键词: 改良CCI 模型 机械痛敏 热痛敏 自发放电 |
| 英文关键词: Modified Chronic constriction injury model Mechanical sensitivity Thermal sensitivity Spontaneous discharges |
| 基金项目:国家自然科学基金项目(10772101，30770701，30900443) 以及国家高技术研究和发展项目(863) (2007AA02Z310) |
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| 中文摘要: |
| 目的：应用改良CCI 模型研究外周神经损伤后痛觉过敏和自发放电各自特征及相互关系。方法：雄性SD 大鼠，随机分为
CCI 组和Sham 组，分别于术前1 天和术后1、4、7、9、11、14 天测定机械刺激缩足反射阈值和热缩腿反射潜伏期，同时选取术侧机
械刺激缩腿反射阈值低于4g 或者术侧和健侧热缩腿反射潜伏期差异大于2s 的CCI 模型大鼠观察术后4-14 天损伤区自发放电
活动。结果：神经纤维损伤后，机械痛敏和热痛敏随时间表现为逐渐增强，同时在损伤区观察到三类放电模式：整数倍放电﹑阵发
放电和周期放电。结论：术后大鼠机械痛阈和热痛阈逐渐降低，机械痛敏的产生和损伤区自发放电活动关系密切，不同的放电模
式可能代表不同的传入信息。 |
| 英文摘要: |
| Objective: To investigate characteristic and the relationship of the hyperalgesia and spontaneous discharges in modified
CCI rat. Methods: Male adult SD rats were randomly divided into experiment group(CCI) and control group(Sham).The mechanical
withdrawal threshold(MWT) and thermal withdrawal latency(TWL)were detected before operation and on 1d,4d,7d,9d,11d,14d after operation.
The rats with MWT less than 4 g or with a TWL the difference of which was higher than 2 s between ipsilateral and contralateral
hind paws were selected and used in the subsequent electrophysiological studies. Results: Mechanical sensitivity and thermal sensitivity
increased significantly in the experiment group compared with that in control group. There were three different Firing patterns: Integer
multiple bursting, Intermittent period spiking and Periodic spiking. Conclusion: Threshold of mechanical and thermal pain decreased
gradually after surgery and the abnormal discharge and the mechanical sensitivity were very close to each other. Different firing patterns
may indicate different afferent information. |
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