| 张娟娟1 陈永平2 张天峰1 吴秀霞1.钙黏附素和β- 连接素与宫颈上皮内瘤变进展的关系[J].,2011,11(18):3491-3493 |
| 钙黏附素和β- 连接素与宫颈上皮内瘤变进展的关系 |
| Expression and the Significance of E-cadherin and β-cateninin Cervical Intraepithelial Neoplasia |
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| DOI： |
| 中文关键词: 钙黏附素 β- 连接素 宫颈上皮内瘤变 宫颈肿瘤 免疫组化 |
| 英文关键词: E-cadherin β-catenin Cervical Intraepithelial Neoplasm Cervical Carcinoma Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：观察钙黏附素(E-cadherin)和β- 连接素(β-catenin)在不同级别宫颈上皮内瘤变组织中的表达，探讨其与宫颈上皮内
瘤变进展的关系。方法：采用免疫组化法检测51 例宫颈组织病理存档石蜡包埋组织钙黏附素(E-cadherin) 和β- 连接素
(β-catenin)的表达，阳性信号采用图像分析仪进行定量分析。结果：E-cadherin 在柱状上皮移位组及CIN I 组、CIN II 组、CIN III 组
中的平均光密度值（AOD）分别为：0.0866±0.0392、0.073±0.0122、0.0467±0.0056、0.0396±0.0097；β-catenin 在柱状上皮移位组
及CIN I 组、CIN II 组、CIN III 组中的平均光密度值（AOD） 分别为：0.1101±0.0116、0.1016±0.0108、0.0711±0.0062、0.0515±
0.0091。随着CIN 病变的升级，钙黏附素和β- 连接素的表达均呈下降趋势，二者的平均光密度值（AOD）正相关(r =2.546，P＝
0.018<0.05)。结论：钙黏附素、β- 连接素与宫颈上皮内瘤变的进展相关，在估计CIN 的预后中有一定意义。 |
| 英文摘要: |
| Objective: To investigate the expression and the significance of E-cadherin and β-catenin in cervical intraepithelial
neoplasia. To analysis whether a relationship between expression of E-cadherin and β-catenin and progression of cervical intraepithelial
neoplasia. Methods: E-cadherin and β-catenin expressions in 51 cases of CIN and columnar ectopy was detected by Immunohistochemistry
method and automatic image analysis technique. Results: The AOD values of E-cadherin in the columnar ectopy group,CIN I group,
CIN II group and CIN III group are separately: 0.0866± 0.0392,0.073±0.0122,0.0467±0.0056,0.0396±0.0097. The AOD values of
β-catenin in the columnar ectopy group,CIN I group,CIN II group and CIN III group are separately: 0.1101±0.0116,0.1016±0.0108,
0.0711±0.0062,0.0515±0.0091.The expressions of E-cadherin and β-catenin in cervical intraepithelial neoplasias are positive correlation
notablely (r=2.546,P<0.05). Conclusions: The results indicate that decreased E-cadherin and β-catenin expression might be related
to the progression of cervical intraepithelial neoplasia, the two indicator might be a useful tool to evaluate the prognosis of CIN. |
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