| 徐丽洁1 李香2 陈廷雷2 王传文2 李霞2.儿童特发性血小板减少性紫癜与人巨细胞病毒感染的关系[J].,2012,12(2):298-300 |
| 儿童特发性血小板减少性紫癜与人巨细胞病毒感染的关系 |
| The Relationship Between Idiopathic Thrombocytopenic Purpuraand Human Cyto-megalovirus Infection in Children |
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| DOI： |
| 中文关键词: 人巨细胞病毒 特发性血小板减少性紫癜 儿童 免疫状态。 |
| 英文关键词: Human Cytomegalovirus ( HCMV) Idiopathic thrombocytopenic purpura Children Immune condition |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨特发性血小板减少性紫癜的治疗转归与巨细胞病毒感染的关系。为临床合理有效地治疗ITP 提供部分参考。方
法：用ELISA 法和流式细胞仪分别检测患儿血清HCMV 抗体及外周血淋巴细胞亚群。选取2005.1-2006.12 在本院儿科就诊的68
例新发ITP 患儿，将其按有无HCMV 感染分为HCMV 感染组和非感染组，比较二者的免疫状态，近期（两周）疗效，远期（六月）疾
病转归之间的关系。结果：68 例ITP 患儿中HCMV 感染30 例，非HCMV 感染ITP 存在T 淋巴细胞亚群的异常，即CD4+ 细胞减
低，CD8+ 细胞升高。HCMV 感染患儿T 淋巴细胞总数亦降低，CD4+ 细胞下降明显。近期疗效无明显差异，远期转归相比较有统
计学意义。结论：HCMV 感染诱发的细胞免疫异常是儿童ITP 发病及病程迁延的重要因素。应同时进行抗病毒和免疫治疗。 |
| 英文摘要: |
| Objective: Study the correlation between Human Cyto-megalovirus infection and idiopathic thrombocytopenic purpurc.
Methods: 68 children with ITP treated in our department between January ,2005 to December, 2006, were divided into two groups
based on whether they were infected with HCMV or not. The two groups were compared with regard to the cell immune conditions,
short-term effectiveness of treatment (two weeks) and long-term results (over six months). Results: 30 out of 68 (44.12%)ITP children
were found with HCMV infection ,and the lever of CD4 in ITP with HCMV infection was lower than that in ITP without HCMV infection.
Conclusion: ITP patients with HCMV infection have lowered and disordered cellular immunity, a simultaneous antivirus and immunotherapy
are necessary. |
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