| 陈军浩张葵△.天然调节T 细胞与诱导调节T 细胞的生物学特性[J].,2012,12(2):389-392 |
| 天然调节T 细胞与诱导调节T 细胞的生物学特性 |
| Characteristics of Natural and Induced Regulatory T Cells |
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| DOI： |
| 中文关键词: 调节T 细胞 天然调节T 细胞 诱导调节T 细胞 细胞治疗 |
| 英文关键词: Regulatory T cells nTreg iTreg Cellular therapy |
| 基金项目:南京市医学发展重点项目（ZKX08030） |
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| 中文摘要: |
| CD4+CD25+FOXP3+ 的调节T 细胞（regulatory T cells，Treg）在维持机体免疫平衡方面起着重要的作用。体外扩增Treg 细
胞用于治疗自身免疫病、哮喘及诱导器官移植免疫耐受引起人们极大的兴趣。Treg 细胞可分为2 个亚群，分别为nTreg 和iTreg，
两者有不同的生物学特性。nTreg 在特定条件下，可以分泌具有促进炎症的IL-17；iTreg 在体内可丢失FOXP3，失去其免疫抑制功
能。Treg 细胞用于临床治疗，还有许多问题需要研究解决。 |
| 英文摘要: |
| CD4+CD25+FOXP3+ regulatory T cells is more important for keeping the immune system in homeostatic balance.
There is more increasing attention in large-scale expansion of regulatory T cells for therapeutic autoimmune disease, asthma and inducing
immune tolerance for organ transplant. There are two subgroup in regulatory T cells, named naturally occurring Tregs (nTreg) and inducible
Tregs(iTreg), respectively. There are some differences between nTreg and iTreg cells in biology characteristics. The nTreg is able
to produce IL-17 cytokine which can promote proinflammatory under specific environment. The iTreg may lose FOXP3 expression and
miss its immune suppression. Many questions must be solved before Tregs as cellular therapeutics. |
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