| 杨美兰1 邓亚平2 刘志红2.PRL-3 和VEGF 在结肠癌中表达的临床病理研究[J].,2012,12(3):485-488 |
| PRL-3 和VEGF 在结肠癌中表达的临床病理研究 |
| Expression and Clinical Significance of PRL-3 and VEGFin Colon Carcinoma |
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| DOI： |
| 中文关键词: 结肠癌 促肝再生磷酸酶蛋白 血管内皮细胞生长因子 免疫组织化学 |
| 英文关键词: Colon carcinoma Phosphatase of Regenerating Liver-3 Vascular endothelial growth factor Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨PRL-3 和VEGF 在结肠癌组织中的表达及其临床意义。方法：用免疫组织化学技术检测50 例结肠癌组织及相应
癌旁组织中PRL-3 和VEGF 的表达，并分析其与患者临床病理变量的关系及其对预后的影响。结果：PRL-3 和VEGF 在结肠癌组
织表达上调明显高于癌旁组织,有统计学意义。PRL-3 和VEGF 的阳性表达率与肿瘤分化程度、淋巴结转移、及TNM 分期有关。
而与年龄、性别、肿瘤大小无关（P＞0.05）。PRL-3 和VEGF 表达上调者的中位生存时间明显短于低表达者。PRL-3 和VEGF 表达
有显著相关性。结论：PRL-3 和VEGF 与肿瘤分化、侵袭、转移和预后不良密切相关。 |
| 英文摘要: |
| Objective: To investigate the expression of PRL-3 and VEGF in colon carcinoma and its clinical significance.
Methods:The expression of PRL-3 and VEGF was investigated by SP (Streptavidin Perdcidase) immunohistochemical method. Results:
The positive expression rate of PRL-3 and VEGF in colon carcinoma was significantly higher than para-carcinoma tissues. The
expression of PRL-3 and VEGF was associated with tumor differentiation, lymph node metastasis and TNM stage, but not with age,
gender, tumor diameter. The PRL-3 and VEGF high expression group had a significantly poorer median survival time than the low
expression group. PRL-3 and VEGF expression in colon carcinoma have significant relation. Conclusion: PRL-3 and VEGF are closely
related to the factors indicating differentiation, metastasis, poor prognosis. |
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