| 贺慧鹏廖爱军△.MicroRNA 与肿瘤的研究进展[J].,2012,12(4):757-759 |
| MicroRNA 与肿瘤的研究进展 |
| Progress of Research on MicroRNA and tumor |
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| DOI： |
| 中文关键词: microRNA 肿瘤 基因表达 |
| 英文关键词: Visfatin Visceral adipocyte Type 2 Diabetes mellitus |
| 基金项目:兰州军区科研基金项目（XLH2009027） |
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| 中文摘要: |
| microRNA 是近年来发现的与基因表达调控相关的一类非编码小分子单链RNA，长度约21-22 个碱基对构成，通过与靶
mRNA 碱基对特异结合，引起靶mRNA 降解或翻译抑制，调控基因转录后的表达。microRNA 通过干预基因表达，从而对细胞的
分化、增殖、凋亡、新陈代谢等多项生命活动进行调控。microRNA 的表达异常可以引起细胞的分化、增殖、凋亡的异常，这与肿瘤
的发生、发展关系密切。其作为一个新的分子生物学标志，在肿瘤的诊断、治疗中有着重要的潜在价值。 |
| 英文摘要: |
| MicroRNA discovered recently is a class of non-coding single-stranded RNA molecules associated with the regulation
of gene expression. It is length of about 21-22 base pairs, and can cause inhibition of target mRNA degradation or translation by specific
binding of the target mRNA base pairs, furtherly regulated gene expression of post-transcription. MicroRNA can regulate cell's
differentiated, proliferation, apoptosis, metabolism by interfering with gene expression. Abnormal expression of microRNA can cause
disorder of cell's differentiated, proliferation, apoptosis, metabolism, which is closely related to the occurrence and development of tumor.
MicroRNA is biological markers of new molecular, which is important potential value in diagnosis and treatment of tumor. |
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