| 涂超1 殷俊1 刘瑛2△.内源性硫化氢在中枢神经系统中的作用研究进展[J].,2012,12(5):975-978 |
| 内源性硫化氢在中枢神经系统中的作用研究进展 |
| The Current Study of Endogenous Hydrogen Sulfide (H2S) and Its Rolein Central Nervous System |
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| DOI： |
| 中文关键词: 内源性硫化氢 神经递质 生理作用 中枢神经系统 |
| 英文关键词: Endogenous hydrogen sulfide Neurotransmitter Physiological function Central nervous system |
| 基金项目:中南大学大学生创新课题（YC09141） |
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| 中文摘要: |
| 硫化氢是继NO 和CO 之后发现的又一种新的气体信号分子，其被认为是一种神经递质，在中枢神经系统中起着重要的作
用。内源性H2S 主要由胱硫醚-β 合酶(CBS)和胱硫醚γ- 裂解酶(CSE)合成，其不仅可以直接作用于中枢神经系统发挥作用，还能
通过抗氧化、调节神经内分泌及脑血管功能，进而间接影响中枢神经系统功能，具有广泛的生理作用。近年来，越来越多的研究发
现内源性H2S 在AD、热惊厥、PD、脑卒中、缺血再灌注脑损伤及遗传性疾病脑损害等神经系统疾病的发病过程中也起着重要作
用。本文简要介绍H2S 的生化和生理特点，并总结其在中枢神经系统中作用的进展。 |
| 英文摘要: |
| Hydrogen sulfide (H2S), a newly discovered gaseous signal molecular alongside with nitric oxide (NO) and carbon
oxide (CO), is now recognized as a neurotransmitter and plays an important role in central nervous system. The production of endogenous
H2S from L-cysteine is catalysed primarily by two enzymes, cystathionine-β-synthase (CBS) or cystathionine-γ-lyase (CSE). H2S has
various physiological functions on central nervous system, not only can it act on it directly, but also exert significant effects indirectly
through anti-oxidation, modulating neuroendocrine and cerebral vascular function. Recently, evidences have been accumulated to
demonstrate that endogenous H2S has also been involved in the regulation of the pathogenesis of some nervous system disease, including
Alzheimer disease, febrile seizures, Parkinson's disease, cerebral stroke, ischemia-reperfusion injury and the brain damage of hereditary
disease. This article overviews the biochemistry and physiology of H2S, summarizes its role in central nervous disease and outlines the
potential options for the therapeutic exploitation of H2S. |
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