| 崔迪韩邦旻荆翌峰夏术阶△.性激素受体在膀胱肿瘤生存预后中的临床价值[J].,2012,12(7):1261-1264 |
| 性激素受体在膀胱肿瘤生存预后中的临床价值 |
| Expression of Sex Hormone Receptors in Bladder Urothelial Carcinoma andits Correlations to Clinicopathological Features and Survival Outcomes |
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| DOI： |
| 中文关键词: 雄激素受体 雌激素β 受体 膀胱癌 |
| 英文关键词: Androgen receptor Estrogen receptorβ Urothelial carcinomas |
| 基金项目:上海市自然科学基金(10ZR1423800)，上海交通大学医学院博士生创新基金(BXJ201136) |
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| 中文摘要: |
| 目的：观察性激素受体(雄激素受体和雌激素β 受体，AR 和ERβ)在膀胱癌中的表达，通过它们与临床病理特征和术后复发
预后的相关分析来探讨性激素受体的临床意义与价值。方法：采用免疫组织化学SP 法检测AR 和ERβ 蛋白在64 例膀胱尿路上
皮癌的表达。显微镜下随机选取5 个400×高倍视野，每个视野计数100 个癌细胞中的阳性细胞数，通过计算染色阳性的细胞率
来评估受体蛋白的表达情况。结果：两种性激素受体蛋白均阳性定位于细胞核中。AR 阳性表达率为26.6%，ERβ 阳性率为
81.2%。AR 和ERβ 的阳性表达率在男女性别方面均无统计学差别(P=0.1982, 0.0669)。随着膀胱癌病理分级升高，AR 和ERβ 的阳
性表达率均增高(P=0.0182, 0.0360)。同时，AR 和ERβ 的表达与患病年龄，膀胱内肿瘤数目，肿瘤大小，肿瘤的临床分期均无统计
学相关性（P 均＞0.05）。术后随访患者时间为2-81 月，生存分析显示：AR 与肿瘤的复发间隔期和5 年复发率相关(P=0.0442)。ERβ
则与肿瘤患者的总生存期相关(P=0.0001)。阳性表达AR 的患者，复发间隔时间增长，5 年复发率较低；ERβ 阳性患者总生存期较
长。结论：性激素受体AR 和ERβ 阳性表达于临床膀胱癌组织中,并且均与膀胱癌的分化密切相关。这提示AR 和ERβ 可能在膀
胱癌的发生发展中起一定作用。同时，两种蛋白还能作为评估膀胱癌复发预后的预测指标。 |
| 英文摘要: |
| Objective: To investigate the expression of sex hormonal receptors (Androgen receptor and Estrogen receptor β, AR
and ERβ) in urothelial carcinomas, and to find the relationship between clinicopathological features and sex hormonal receptors, as well
as survival outcomes. Methods: AR and ERβ expressions were measured by immunohistchemistry in 64 TURBT or partial cystectomy
samples, using streptavidin-biotin peroxidase method. Results: Positive expression of AR and ERβ were noted in 17 (26.6%) and 52
(81.2% ) specimens, respectively. No statistically significant difference in AR and ER β expressions between men and women was
observed (P＞0.05). Patients with more poorly differentiated bladder cancer were accompanied with higher AR and ERβ expressions
(P=0.0182, P=0.0360). There was no statistically significant difference in age of onset, tumor multiplicity, tumor diameter, clinical tumor
stage between sex hormonal receptors positive and negative cases. Positive AR expression increased recurrence-free survival rate while
no significant association was found between it and cancer-special survival rate. Meanwhile, positive ER βexpression increased
cancer-sepcial survival rate ,with no association with recurrence-free survival rate. Conclusions: AR and ERβexpressions were associated
with differentiation in bladder urothelial carcinoma, which means they might play roles in the development and progression of bladder
cancer. Furthermore, AR and ERβ might be options for postoperative recurrence and cancer-related survival prediction. |
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