| 韩文娟张红鸭康娟胡萌萌贾宏阁.多发性肌炎肌组织中Th17 细胞的浸润[J].,2012,12(7):1277-1279 |
| 多发性肌炎肌组织中Th17 细胞的浸润 |
| The Infiltration of Th17 Cells in Muscle Tissues of Polymyositis |
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| DOI： |
| 中文关键词: 多发性肌炎 Th17 细胞 白细胞介素17（IL-17） |
| 英文关键词: Polymyositis Th17 Cells Interleukin-17 |
| 基金项目:国家自然科学基金资助项目（81171181） |
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| 中文摘要: |
| 目的：探讨多发性肌炎（PM）患者肌肉炎性组织中是否存在Th17 细胞及数量多少。方法：临床和病理诊断确诊的多发性肌炎
患者16 例；对照组来自非炎性肌病患者6 例。应用免疫荧光组织化学方法检测Th17 淋巴细胞的定位及数量。结果：与非肌炎患
者比较，免疫荧光组织化学检测到肌炎患者肌肉组织中IL-17 表达阳性，主要分布在细胞内，且细胞数量的多少与炎症的严重程
度成正相关。结论：Th17 细胞有可能参与了多发性肌炎的发病过程。 |
| 英文摘要: |
| Objective: To investigate the existence and quantities of Th17 cells in the muscle tissue of patients with polymyositis.
Methods: 16 patients with polymyositis after a diagnosis of clinical and pathological; control group is 6 patients from non-inflammatory
myopathy. Detect the location and the number of IL-17-producing effector T helper cells through immunofluorescence. Results:
Compared to non-inflammatory myopathy, IL-17 positively expresses in patients with polymyositis which is mainly in cells, and the
number of Th17 cells is positively related to the severity of inflammation. Conclusions: The Th17 cells may be involved in the
pathogenesis of polymyositis. |
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