| 郑腾飞沃金善△ 赵青张文忠郭洁.冠心病合并代谢综合征患者的冠状动脉病变特点及与
代谢综合征组分的相关性研究[J].,2012,12(8):1524-1529 |
| 冠心病合并代谢综合征患者的冠状动脉病变特点及与
代谢综合征组分的相关性研究 |
| The Characteristics of Coronary Artery Disease in Patients AccompaniedbyMetabolic Syndrome and the Associations with the Componentsof Metabolic Syndrome |
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| DOI： |
| 中文关键词: 冠心病 代谢综合征 Gensini 积分 危险因素 |
| 英文关键词: Coronary artery disease Metabolic syndrome Gensini score Risk factors |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨冠心病合并代谢综合征(metabolic syndrome，MS)患者的冠脉病变特点及冠心病与MS 各组分的相关性。方法：选
取540 例冠心病患者为研究对象，其中合并MS 患者164 例，非合并MS 患者376 例，并将所有患者根据MS 的组分个数进行分
组，比较冠心病合并MS 的病变特点、MS 组分个数对冠状动脉病变程度的影响及冠状动脉病变程度与代谢综合症各组分的相关
性；结果：①冠心病合并MS 组BMI、FBG、TG、LDL-C、TC、UA、FIB、高血压分级等指标较非MS 组高，差异有统计学意义（P<0.01），
HDL-C、LVEF 较非MS 组低，差异有显著性（P<0.01）；②MS 组冠脉Gensini 积分较高，三支病变、主干病变发生率高,差异有显著
性（P<0.01）；③随着合并MS 组分个数的增加，冠脉Gensini 积分也逐渐增加，各组间比较有显著性差异（P<0.01）；④冠脉Gensini
积分与MS 组分BMI、高血压分级、TG、TC、LDL-C、UA 等指标存在正相关（P<0.05)，与性别、HDL-C 存在负相关（p<0.01)；调整传
统危险因素后，Gensini 积分与MS 的组分数显著相关（r=0.739、P<0.01)。结论：冠心病患者有较高的MS 患病率，冠心病合并MS
患者冠脉病变程度更重，且以多支病变、主干病变为主；随着合并MS 组分个数的增加，冠脉病变程度也呈加重趋势；MS 的各个
组分均与冠状动脉病变程度显著相关，可以作为冠心病严重程度的预测指标。 |
| 英文摘要: |
| Objective: To investigate the characteristics of CHD in patients accompanied by metabolic syndrome(MS) and to study
the relationship between the severity of coronary atherosclerosis and the components of MS. Methods: 540 cases of coronary heart
disease patients were chosen, of which 164 cases were combined with MS, 376 cases were not combined with MS. All patients were
divided into five groups, based on the number of components of MS; and also be divided into two groups, according to the diagnostic
criteria for MS. The extent of coronary artery lesions and other indicators in CHD patients between different groups were compared, and
the relationships between the degree of CHD and ingredients of MS was explored. Results: ①The indicators of BMI, FBG, TG, LDL-C,
TC, UA, FIB, high blood pressure levels were higher in patients of MS group than that in non-MS group, while the HDL-c, LVEF were
lower in MS group, the differences were significant (P<0.01). ② The patients accompanied by MS had higher gensini score and higher
incidence of trunk lesions and triple-vessel lesions, lower incidence of single-vessel lesions, the differences were significant (P<0.01). ③
Coronary Gensini score gradually increased, with the combined increasing in the number of MS ingredients, the differences between five
groups were significant (P<0.01). ④ Coronary Gensini score had positive correlation with the BMI, Blood pressure levels, TG, TC,
LDL-C, UA (P<0.05). while it had negative correlation with gender, HDL-c. Adjustment for traditional risk factors, and the relationship
between Gensini score and the number of MS ingredients was significant(r = 0.739, P<0.01). Conclusion: Coronary heart disease patients
had a higher prevalence of MS, when accompanied by MS. The extent of CHD was more severe, mostly triple-vessel lesion and trunk
lesion; With the combined increase in the number of MS ingredients, the degree of CHD tendED to be worse; The components of MS
were significantly related to CHD, can be used as predictors of the severity of coronary heart disease. |
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