| 朱敏1 王彬1 王枫1 郑刚2 张雪平1△.ω-3 多不饱和脂肪酸对PTSD-SPS 大鼠行为学影响的研究[J].,2012,12(12):2290-2293 |
| ω-3 多不饱和脂肪酸对PTSD-SPS 大鼠行为学影响的研究 |
| Effects of ω-3 Polyunsaturated Fatty Acids on Behavioral Changes of Ratswith PTSD-SPS |
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| DOI： |
| 中文关键词: PTSD ω-3 多不饱和脂肪酸 高架十字迷宫实验 旷场实验 |
| 英文关键词: PTSD ω-3 polyunsaturated fatty acids Elevated plus maze test Open-field test |
| 基金项目:国家自然科学基金(30972428) |
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| 中文摘要: |
| 目的：观察饲料中添加ω-3PUFAs 对PTSD-SPS 大鼠焦虑/ 抑郁行为的防护作用。方法：将40 只健康成年雄性SD 大鼠随机
分为正常对照组、PTSD-SPS 模型组、60 % ω-3PUFAs+ PTSD-SPS 模型组1、60 % ω-3PUFAs + PTSD-SPS 模型组2。采用高架十字
迷宫实验和旷场实验评价实验组大鼠的焦虑/ 抑郁行为变化。结果：与对照组相比，SPS 模型组大鼠进入开放臂的次数比例和时
间比例明显减少；中央格停留时间明显缩短（5.56 ± 0.21）s，穿格次数明显减少（30.23 ± 5.96）次，差异均显著（P＜0.05）。与SPS
模型组相比，60 % ω-3PUFAs 的SPS 组大鼠进入开放臂的次数比例和时间比例明显增加；中央格停留时间明显延长（9.88 ±
1.14）s，穿格次数明显增加（43.22±4.35）次，差异均显著（P＜0.05）；与对照组相比没有显著差异。结论：膳食补充ω-3 多不饱和脂
肪酸可以降低PTSD-SPS 大鼠焦虑/ 抑郁程度。 |
| 英文摘要: |
| Objective: To investigate the effects of ω-3PUFAs on the anxiety and depression-like behaviors of rats with
PTSD-SPS. Methods: Forty male SD rats were randomly and equally divided into 4 groups: control group, PTSD-SPS group, 60 %
ω-3PUFAs + PTSD-SPS group 1, 60 % ω-3PUFAs + PTSD-SPS group 2. The behavioral changes were evaluated by the EPM test system
and the OF test system. Results: In the EPM test, the number of entering the open-arm and the open-arm detention time in the
PTSD-SPS group were significantly lower than that of the control group (P＜0.05). The time of resting on the center lattice and times of
spanning lattice in the SPS group decreased (5.56 ± 0.21) s and (30.23 ± 5.96) times in the OF test (P＜0.05), respectively. The number
of entering the open-arm and the open-arm detention time in the ω-3PUFAs group were significantly lower than that of the SPS group
(P＜0.05) in the EPM test. The time of resting on the center lattice and times of spanning lattice were increased (9.88 ± 1.14) s and
(43.22±4.35) times in the OF test (P＜0.05), respectively. There were no significance difference between the ω-3PUFAs group and the
control group. Conclusion: Dietary Supplement of ω-3PUFAs could reduce the anxiety and depression-like behaviors of PTSD-SPS model
rats. |
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