| 赵统1 王丽2 胡敏2 吕坤聚2△ 蒋捍东1.非小细胞肺癌中NF-κ B、VEGF 的表达及其与肿瘤血管形成的研究[J].,2012,12(19):3605-3609 |
| 非小细胞肺癌中NF-κ B、VEGF 的表达及其与肿瘤血管形成的研究 |
| Expressions of NF-κ B and VEGF in Non - Small Cell Lung Cancer and theRelationships between them and Tumor Angiogenesis |
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| DOI： |
| 中文关键词: 肺肿瘤 NF-κ B P65 VEGF 免疫组织化学 |
| 英文关键词: Lung neoplasm NF-κ B P65 VEGF Immunohistochemistry |
| 基金项目:山东省自然科学基金项目（Y2007C113）；山东省科技发展计划项目（2010GWZ20216） |
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| 中文摘要: |
| 目的：探讨核因子-κ B（NF-κ B）和血管内皮生长因子（VEGF）在非小细胞肺癌中的表达及其与肿瘤血管形成的关系。方法：
应用免疫组织化学方法检测56 例非小细胞肺癌及20 例癌旁肺组织中的NF-κ B P65、VEGF 的表达，并用抗CD34 测定肿瘤血管
的密度（MVD）。结果：(1)在非小细胞肺癌中NF-κ B P65、VEGF 的表达阳性率分别为83.9 %（47/56）、69.6 %（39/56），明显高于癌
旁组织（P＜0.05）；(2)NF-κ B P65 的表达在不同的TNM 分期、淋巴结及胸腔积液、吸烟的分组之间差异有统计学意义，VEGF 的
表达在淋巴结及胸膜转移之间差异有统计学意义;(3) NF-κ B P65、VEGF、MVD 三者间存在明显相关性。结论：NF-κ B、VEGF 异
常表达与NSCLC 的发生、发展及肿瘤血管的形成密切的关系。 |
| 英文摘要: |
| Objective: To investigate the expression of vascular endothelial growth factor (VEGF), NF-κB and the relationship
with tumor angiogenesis in non-small cell lung cancer (NSCLC). Methods: Expressions of NF-κ B P65, VEGF in NSCLC（n=56）and
benign tumor tissue (n=20) were detected by immunohistochemical staining. A monoclonal antibody directed against CD34 to identify
intratumoral microvessel density (iMVD). Results: The positive expression rates of NF-κ B P65, VEGF in NSNLC tissue were 83.9%,
69.6% respectively with significantly higher than those of benign tumor tissue (P＜0.05). The expression level of NF-κ B P65 was related
with tumor stages, lymphnode involvement, pleural metastasis and smoking of patients ( P <0.05). The expression level of VEGF was
related to lymphnode involvement and pleural metastasis. There was statistically significant correlation between the expression of NF-κB
P65 and VEGF, NF-κ B P65 and MVD, VEGF and MVD, respectively （P <0.05）. Conclusion: The high expressions of NF-κ B P65 and
VEGF in NSCLC tissues may be related with tumor invasion and angiogenesis. |
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