| Baloucoune Guillaume Antoine 春雷黄思罗.GABABR 异二聚体和GB1-GB1 同二聚体中的GB1 亚基的作用[J].,2012,12(21):4144-4148 |
| GABABR 异二聚体和GB1-GB1 同二聚体中的GB1 亚基的作用 |
| The Role of GB1 Subunit in GABABR Heterodimer and GB1-GB1Homodimer |
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| DOI： |
| 中文关键词: GABABR GB1 GB2 GB1-GB1 同二聚体 激活机制 |
| 英文关键词: GABABR GB1 GB2 GB1-GB1 homodimer Activation mechanism |
| 基金项目:国家自然科学基金项目资助（No. 31100548, No. 30973514） |
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| 中文摘要: |
| GABABR 属于C 族G 蛋白偶联受体，是中枢神经细胞重要的抑制性神经递质受体。在体内GABABR 由GB1 和GB2 两个
基因编码，1998 年以来研究者证实GABABR 是由GB1 和GB2 形成的异二聚体，但近年来的研究表明，GB1 也可以单独形成
GB1-GB1 同二聚体并在体内行使功能。本文系统介绍了GB1 亚基的分类，在GB2 存在或不存在时的表达，以及在GABABR 异二
聚体和GB1-GB1 同二聚体激活过程中所扮演的角色和生理功能；同时也展望了这些研究成果对于基础研究和药学研究的意义。 |
| 英文摘要: |
| GABABR belongs to the Class C G protein-coupled receptor, and it is important inhibitory neurotransmitter receptors
in central nervous system. GABABR is encoding by two genes, GB1 and GB2, and researchers have confirmed that GABABR is heterodimer
formed by GB1 and GB2 since 1998, but recent studies have shown that GB1 could form GB1-GB1 homodimer in the absence
of GB2 and exercise functions in vivo. In present systematically review the different splice variants of GB1, and its expression in the presence
or absence of GB2, and its role in the activation process of GABABR heterodimer and GB1-GB1 homodimer as well as its physiologic
effect in vivo; and also prospect the significance of the above studies in basic research and pharmacology. |
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