| 季宏志许西琳△.基因多态性与慢性阻塞性肺疾病易感性关系研究的新进展[J].,2012,12(23):4569-4571 |
| 基因多态性与慢性阻塞性肺疾病易感性关系研究的新进展 |
| Research Advance on Correlation between Polymorphism of Genetic Geneand Susceptibility to Chronic Obstructive Pulmonary Disease |
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| DOI： |
| 中文关键词: 慢性阻塞性肺疾病 多态性 遗传易感性 |
| 英文关键词: Chronic obstructive pulmonary disease Polymorphisms Genetic susceptibility |
| 基金项目: |
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| 中文摘要: |
| 慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)是一组气流受限为特征的肺部疾病，气流受限不完全可逆，
呈进行性发展。它受遗传因素，环境因素以及遗传- 环境相互作用的影响。目前，虽然其确切的病因及发病机制不甚明了，但是近
年来的研究表明COPD 是一种多基因调控的疾病。本文综述了几个较为重要的遗传基因多态性与COPD 易感性关系的近期研究
进展。 |
| 英文摘要: |
| Chronic obstructive pulmonary disease (COPD) is a slowly progressing lung disease characterized by irreversible
airflow limitation in the lungs. COPD is a complex disease which is influenced by genetic factors, environmental agents, and gene-environmental
interactions. At present, although the etiological factor and pathogenesis of COPD are uncertain,in recent years, studies have
shown that COPD was a muti-gene regulated disease. This paper summarizes the relation of several important genetic gene polymorphisms
and the susceptibility of COPD. |
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