| 杨和旭 梁栋 张茜 范伟伟 李伟杰 刘兵 张东伟 王海昌 曹丰.急性心肌梗死患者冠脉介入治疗后血浆apelin的变化及作用[J].,2014,14(1):108-113 |
| 急性心肌梗死患者冠脉介入治疗后血浆apelin的变化及作用 |
| The Effect of Percutaneous Coronary Intervention on Plasma Apelin inPatients with Acute Myocardial Infarction |
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| DOI： |
| 中文关键词: 急性心肌梗死 Apelin 冠脉介入治疗 2 型糖尿病 |
| 英文关键词: Acute myocardial infarction Apelin Percutaneous coronary intervention Type 2 diabetes |
| 基金项目:国家自然科学基金项目(81090274；81270168)；军队重点项目(BWS12J037) |
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| 中文摘要: |
| 目的：观察急性心肌梗死（AMI）患者围手术期血浆apelin 的表达变化，分析AMI 合并2 型糖尿病（T2DM）患者血浆apelin |
| 英文摘要: |
| Objective:To evaluate the cardiac protection of perioperative plasma apelin of patients with acute myocardial
infarction (AMI) in percutaneous coronary intervention (PCI), and the relationship between apelin and patients with AMI complicated
with type 2 diabetes (T2DM).Method: 72 patients with coronary heart disease diagnosed as AMI by coronary arteriography in the
department of Cardiology in our hospital had completed PCI. Serum was collected before surgery and 0, 4, and 24 hours after surgery for
ELISA to determine plasma apelin-13. A subgroup analysis was further performed on diabetes and non-diabetes AMI patients (20 cases
for each group), and the two groups of patients were followed 6 months post-PCI for main adverse cardiovascular and cerebrovascular
events (MACCE).Results: Apelin was significantly decreased in the postoperative 0h group (AMI patients) compared with that at
baseline preoperatively; and significantly increased in the postoperative 4h and 24h groups compared with that before the PCI.No
significantly difference was noted in apelin between DM and non-DM groups; postoperatively, apelin level was significantly higher in
DM group compared with that in non-DMgroup. No significantly difference was noted with respect to MACCE between both groups in
the postoperative month-6 follow-up. Conclusion: AMI patients had increased plasma apelin expression after PCI, of whom DM patients
had significant increased plasma apelin expression after PCI compared with that of non-DM patients, indicating that PCI coronary
revascularization may promote apelin secretion, and regulate insulin resistance, so as to improve prognosis. |
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