| 杨纾旖
1
地力木拉提 · 艾斯木吐拉
1
王永高
1
阿迪力江· 买买提明
1
栾梅香
1
任智慧
2△.甲状腺特异性抗体与乳腺癌相关性研究的系统评价 *[J].,2014,14(6):1170-1173 |
| 甲状腺特异性抗体与乳腺癌相关性研究的系统评价 * |
| A Systematic Review of Studies in Relationship between ThyroidAutoantibodies and Breast Cancer* |
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| DOI： |
| 中文关键词: 甲状腺特异性抗体 甲状腺过氧化物酶抗体 甲状腺球蛋白抗体 乳腺癌 系统评价 |
| 英文关键词: Thyroid autoantibodies Anti-TPO Anti-TG Breast cancer Systematic review |
| 基金项目:新疆维吾尔自治区自然科学基金面上项目(2011211A084) |
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| 中文摘要: |
| 摘要 目的：评价血清中甲状腺特异性抗体的存在对乳腺癌患病风险的影响，为评估乳腺癌的预后及制定治疗方案提供理论依
据。方法： 计算机检索 Medline （ 1950~2012 ） 、 EMBASE （ 1949~2012 ） 、 Pubmed （1946~2012 ） 、 Current Contents Connect （ 1998~2012 ）
和 Google Scholar （ 1992~2012 ） 等英文数据库。 收集关于甲状腺特异性抗体与乳腺癌(Breast Cancer, BC)相关性分析的横断面研究
或队列研究。 按 Cochrane 系统评价方法， 评价所纳入研究的文献质量， 有效数据采用 RevMan5.2 软件进行系统评价。结果： 最终
纳入 6 项研究， 共计 6945 例患者。系统评价结果显示： 乳腺癌的风险会随血清中甲状腺特异性抗体 （包括甲状腺过氧化物酶抗体
anti-TPO 和甲状腺球蛋白抗体 anti-TG ）的存在而增加 （anti-TPO OR 2.51， 95%CI: 1.94-3.25； anti-TG 2.67, 95%CI: 1.65-4.33 ）。结
论： 乳腺癌的风险会随血清中甲状腺特异性抗体的存在而增加，甲状腺特异性抗体可能为乳腺癌预后的评估以及治疗原则的制
定提供理论基础 |
| 英文摘要: |
| ABSTRACT Objective:To evaluate the effect of the thyroid autoantibodies in serum on breast cancer risks. Methods:Medline
(1950~2012), EMBASE (1949~2012), Pubmed (1946~2012), Current Contents Connect (1998~2012) and Google Scholar
(1992~2012) and other English database were searched. The data on correlation analysis about both thyroid autoantibodies and breast
cancer (Breast Cancer, BC) in cross-sectional or cohort studies were collected. According to the Cochrane Handbook for systematic
method, the quality of the included studies were evaluated by using Review Manager 5.2 software for Meta-analysis. Results:Ultimately
six studies were included, a total of 6945 cases of patients. Meta-analysis results showed that the risk of breast cancer increased with the
presence of serum thyroid autoantibodies including thyroid peroxidase antibodies （ anti-TPO ） and thyroglobulin antibodies （ anti-TG ）(antiTPO OR 2.51, 95% CI: 1.94-3.25; anti-TG 2.67, 95% CI: 1.65-4.33). Conclusion:The risk of breast cancer would increase with the
presence of thyroid autoantibodies in serum which may be used for assessing breast cancer prognosis, and providing a theoretical basis
for the formulation of treatment principles. |
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