| 徐珂1 侯江红2 吴秀娟1 任敏1 张艳1.硝苯地平缓释片联合缬沙坦治疗原发性高血压疗效和
安全性的Meta 分析[J].,2014,14(8):1554-1558 |
| 硝苯地平缓释片联合缬沙坦治疗原发性高血压疗效和
安全性的Meta 分析 |
| The Therapeutic Effect and Safety of Sustained-release Nifedipine Combinedwith Valsartan in The Treatment of Essential Hypertension: A Meta-analysis |
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| DOI： |
| 中文关键词: 硝苯地平 缬沙坦 原发性高血压 Meta 分析 |
| 英文关键词: Sustained-release Nifedipine Valsartan Essential Hypertension Meta-analysis |
| 基金项目: |
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| 中文摘要: |
| 摘要目的：系统评价硝苯地平缓释片联合缬沙坦治疗原发性高血压的疗效和安全性。方法：计算机检索PubMed、Cochrane Library
、CBM、CNKI、VIP 等数据库，按照纳入和排除标准纳入依硝苯地平缓释片联合缬沙坦治疗原发性高血压的随机对照试验
（RCT），并补充检索纳入研究的参考文献；按Cochrane 系统评价方法由两名评价员独立评价纳入文献质量、提取资料并交叉核对
无误后，采用RevMan 5.1 软件进行统计学分析。结果：共纳入4 个RCT，包括共450例患者，其研究质量均为C级。Meta 分析结
果显示：硝苯地平缓释片联合缬沙坦治疗原发性高血压的显效率[RR=1.29, 95%CI(1.08～1.55), P< 0.01]、总有效率[RR=1.19, 95%
CI(1.10～1.29), P<0.01]和无效率[RR=0.38, 95%CI(0.24～0.62), P<0.01]与单用硝苯地平缓释片比较，两组差异有统计学意义，两组
有效率差异无统计学意义[RR=1.02, 95%CI(0.97～1.32), P>0.01]。结论：现有证据表明：硝苯地平缓释片联合缬沙坦治疗原发性高
血压在显效率，总有效率和无效率方面优于硝苯地平缓释片单用，不良反应与苯地平缓释片单用无明显差异，但远期疗效尚不清
楚，尚需更多高质量的随机双盲对照试验证实。 |
| 英文摘要: |
| ABSTRACT Objective:To review the clinical curative effect and safety of sustained- release nifedipine combined with valsartan in
the treatment of essential hypertension. Methods:We electronically searched PubMed, Cochrane Library, CBM, CNKI, VIP. Rando-mized
controlled trials (RCTs) about ustained-release nifedipine combined with valsartan in the treatment of essential hypertension were included,
and the relevant references of the included papers were also searched.Study selection and analysis were undertaken according to the
Cochrane Handbook, and RevMan 5.1 was applied for statistical analyses.Results: Four RCTs involving 450 patients with Cardiac
Arrhythmia were included. The quality grade of all studies were C.The results of meta-analysis showed that the marked effect rate[RR=1.
29, 95%CI (1.08～1.55), P< 0.01], total effective rate [RR=1.19, 95%CI (1.10～1.29), P<0.01]and ineffective rate [RR=0.38, 95%CI
(0.24～0.62), P<0.01]were superior in the combination arm to the sustained-release nifedipine alone arm.There were no significant
difference between the two groups in effective rate [RR=1.02, 95%CI (0.97-1.32), P>0.01]. Conclusion:The current evidence available
shows that the sustained- release nifedipine combined with valsartan in the treatment of essential hypertension may significantly improve
the marked effect rate, total effective rate and reduce the ineffective rate comparing with sustained-release nifedipine alone, and there
were no significant difference was found between the two groups in adverse reaction. However, long-term efficacy are not clear, more
high-quality RCTs should be conducted. |
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