| 周游陈绘颖王江友刘涛苏强刘阳春李浪△.曲美他嗪对大鼠放射性心肌损伤后TNF-α表达的影响*[J].,2014,14(10):1821-1824 |
| 曲美他嗪对大鼠放射性心肌损伤后TNF-α表达的影响* |
| Effects of Trimetazidine on the Expression of TNF-αin Ratsduringradiogenic Myocardial Damage* |
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| DOI： |
| 中文关键词: 放射性心脏损伤 曲美他嗪 TNF-α 大鼠 |
| 英文关键词: Radiogenic myocardial damage Trimetazidine TNF-α Rat |
| 基金项目:国家自然科学基金项目（81160046） |
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| 中文摘要: |
| 摘要目的：放射性心肌损伤是纵膈及胸腔等部位恶性肿瘤放射治疗后发生的严重并发症，目前尚无有效防治方法，而本实验拟
探索曲美他嗪对放射性心肌损伤的保护作用。方法：将45 只SD 大鼠随机分为正常对照组（C 组）、单纯照射组（X 组）、曲美他嗪
治疗组（T 组），每组15 只，其中X组、T 组予以10 Gy/d，共3 天。大鼠照射完毕处死后测定血清cTnI 浓度，心肌组织TNF-琢mRNA
及蛋白的表达。结果：1.X 组与C 组相比，血清cTnI浓度，心肌组织TNF-αmRNA 及蛋白的表达均明显升高（P＜0.05）；2. T
组与C组相比，血清cTnI浓度，心肌组织TNF-αmRNA及蛋白的表达均明显升高（P＜0.05）；3.T 组与X 组相比，血清cTnI浓度，
心肌组织TNF-αmRNA 及蛋白的表达均明显降低（P＜0.05）。结论：曲美他嗪能够通过减少心肌组织TNF-α mRNA及蛋白的表
达，从而有效减轻大鼠放射后心脏炎症反应，以减轻心肌损伤。 |
| 英文摘要: |
| ABSTRACT Objective：Radiogenic myocardial damage is a serious complication of mediastinal and pleural and other parts of
malignant tumor after radiotherapy, there is no effective control methods, and in this study intends to explore the protective effect oftrimetazidine
on radiogenic myocardial damage.Methods：45 SD rats were randomly divided into normal control group (group C),
irradiation alone group(group X), trimetazidine treatment group (T group), 15 rats in each group, X group. T group were given 10 Gy/d, a
total of 3 days, a total dose of 30 Gy X-ray irradiation. Irradiated rats were completed by measuring the concentration of serum cTnI, the
expression of TNF-α protein and mRNA in myocardial tissue. Results：1.Compared with X group and C group, the concentration of
serumcTnI, the expression of TNF- αprotein and mRNA in myocardial tissue were significantly increased (P<0.05); 2. Compared with T
group and C group the concentration of serum cTnI, the expression of TNF-αprotein and mRNA in myocardial tissue were significantly
increased (P<0.05); 3.compared with T group and X group, the concentration of serumcTnI, the expression of TNF-αprotein and mRNA
in myocardial tissue were significantly decreased (P<0.05). Conclusion：Trimetazidine can reduce the expression of TNF- mRNA and
proteinin cardiac tissue, so as to effectively reduce the inflammatory response in heart tissue in rats after radiation, to reduce myocardial
injury. |
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