| 钟林 陈飞 李强 邹兆伟 郑伟 黄宗海.ATBF1 研究综述[J].,2014,14(16):3170-3173 |
| ATBF1 研究综述 |
| Review of the Research on ATBF1 |
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| DOI： |
| 中文关键词: ATBF1 神经系统 乳腺癌 胃癌 肝癌 结直肠癌 |
| 英文关键词: ATBF1 Nervous system Breast cancer Gastric cancer Liver cancer Colon cancer |
| 基金项目:广东省教育部产学研结合项目（2010B090400423） |
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| 中文摘要: |
| AT 模体结合因子1（ATBF1）是一个新发现的抑癌基因，从人肝癌细胞HuH-7中分离得到。ATBF1可与甲胎蛋白基因增强
子中AT 富含原件结合，其表达产物是目前发现的分子量最大的转录调节因子。ATBF1 基因表达过程中，通过选择性剪接产生
ATBF1-A 和ATBF1-B 两种mRNA，这两种mRNA 对AFP 表达的调节具有相互对抗作用。ATBF1-A 是ATBF1基因的主要表达
形式，能抑制癌细胞生长；而ATBF1-B 则能促进癌细胞增殖。ATBF1 作为抑癌基因，为肿瘤的治疗带来新希望，但目前学术界对
ATBF1的研究仍然有限。本文重点对ATBF1 在神经系统、乳腺癌、胃癌、肝癌、结直肠癌以及其他肿瘤中的研究作综述，以期进一
步明确ATBF1 的抑癌机制。 |
| 英文摘要: |
| AT motif binding factor 1(ATBF1) was a newly discovered tumor suppressor gene isolated fromhuman liver carcinoma
cell line HuH-7.ATBF1 can combine the area of AT original in alpha fetoprotein gene enhancer and its expression product was currently
the largest transcripts regulator in molecular weight. In the expression of ATBF1, it produced two mRNA (ATBF1-A and ATBF1-B) by
alternative splicing. These two mRNA has a mutual effect on the regulation of AFP expression. ATBF1-A is the main form in the expression
of ATBF1 gene and can inhibit the growth of cancer cell while the ATBF1-B can promote the proliferation of cancer cells. ATBF1
has brought new hope for the treatment of tumor as a tumor suppressor gene, but the current research of ATBF1 is still far from enough.
This review focuses on the reseach on ATBF1 in nervous system, breast cancer, gastric cancer, liver cancer, colon cancer and other tumors
to further clarify the anticancer mechanismof ATBF1. |
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