| 边艳超1，2 牧仁1，3 李云章4 关伟军1△ 马月辉1△.不同物种诱导性多潜能干细胞研究进展及应用*[J].,2014,14(20):3960-3963 |
| 不同物种诱导性多潜能干细胞研究进展及应用* |
| Progress in Induced Pluripotent StemCells of Different Species* |
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| DOI： |
| 中文关键词: 诱导性多潜能干细胞 不同物种 再生医学 临床应用 |
| 英文关键词: Induced pluripotent stemcells Different species Regenerative medicine Clinical application |
| 基金项目:农业部转基因生物新品种培育科技重大专项（2011ZX08009-003-006；2011ZX08012-002-06） |
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| 中文摘要: |
| 摘要：将特定的转录因子转入细胞并使其重编程后，获得与胚胎干细胞极其相似的多潜能性干细胞，称为诱导性多潜能干细胞
（induced Pluripotent StemCells, iPS），它是由日本Yamanaka研究小组首次构建并命名。iPS细胞具有极强地自我更新和多项分化
潜能，有发育和分化形成机体内几乎所有组织细胞类型的潜能，从而构成机体各种复杂的组织器官，且避免了在伦理、道德、宗
教、法律和免疫排斥等诸多问题。随着iPS 技术的不断发展，不同物种的iPS 细胞相继产生，为细胞代替治疗、疾病模型的建立和
药物筛选及再生医学等注入了新的活力。目前，iPS 细胞的研究尚处于初级阶段，在临床应用上还存在诸多问题，本文将对近年来
不同物种iPS 细胞的产生、应用，及我们未来面临的问题和挑战进行综述。 |
| 英文摘要: |
| ABSTRACT:The the pluripotent stem cells which are very similar with embryonic stem cells and obtained by transcribing the
specific transcription factors into the cells and reprogramming, were known as the induced pluripotent stem cells (iPS). It was built and
named by Yamanaka team from Japan. The iPS cells have extremely self-renewal and multiple differentiation. Development and
differentiation to form all types cell of the body, so as to constitute to complex tissues and organs. The iPS cells also avoid the ethical,
moral, religious, legal, immune rejection and many other issues. With the iPS technology evolving, the iPS cells of different species have
generated. The iPS cells for cell replacement therapy, establishment of disease models, drug screening and regenerative medicine has
injected vitality. Currently, the technology of iPS is still in primary stage. There are still many problems in the preparation and clinical
application. This article will review the generation and application of iPS cells of different species, and we will face problems and
challenges. |
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