| 王全晖 郭树军 张春旭 张元浩 郭宁辉.IGF-Ⅱ、IGF-l R、IGFBP-3 在结直肠癌中的表达及诊断价值研究[J].,2014,14(24):4698-4700 |
| IGF-Ⅱ、IGF-l R、IGFBP-3 在结直肠癌中的表达及诊断价值研究 |
| Expression and Diagnostic Value of IGF- Ⅱ, IGF-l R, IGFBP-3in Colorectal Cancer |
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| DOI： |
| 中文关键词: 阳性率 结直肠癌 诊断 表达 |
| 英文关键词: Positive rat Colorectal cancer Diagnosis Expression |
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| 中文摘要: |
| 目的：探讨结直肠癌中IGF-Ⅱ、IGF-l R以及IGFBP-3 等的阳性表达及诊断价值。方法：收集我院45 例结直肠癌、33 例炎性
息肉、40例腺瘤以及35 例正常肠粘膜组织予以免疫组织化学SP 法进行IGF-Ⅱ、IGF-l R以及IGFBP-3 检测，并统计结直肠腺瘤
不同组织类型和结直肠癌不同Dukes 分期的阳性表达差异。结果：结直肠癌组织中IGF-Ⅱ、IGF-l R以及IGFBP-3 表达均呈高阳
性率，并且显著高于其他3 组（P<0.05）。结直肠腺瘤管状、混合型、绒毛状等不同组织类型IGF-Ⅱ、IGF-l R 以及IGFBP-3 表达阳性
率呈逐渐增高趋势，绒毛状腺瘤显著高于其他两型（P<0.05）。45 例结直肠癌中，Dukes分期A、B两期显著低于C期和D期，比较
差异具有显著性（P<0.05）。结论：IGF-Ⅱ、IGF-l R 以及IGFBP-3可能在结直肠腺瘤发生、发展及进展为结直肠癌的过程中起一定
作用，对结直肠癌早期诊断具有一定价值。 |
| 英文摘要: |
| Objective:To investigate the value of positive expression and diagnosis of colorectal cancer IGF- II, IGF-l R and
IGFBP-3 etc.Methods:45 cases of colorectal cancer, 33 cases of inflammatory polyp, 40 cases of adenoma, 35 cases of normal intestinal
mucosa in our hospital were selected , immunohistochemical SP method was used to detect IGF-Ⅱ , IGF-l R and IGFBP-3, the positive
expression of different tissues of colorectal adenoma and different type Dukes colorectal cancer staging were compered.Results:The
colorectal cancer tissue showed a high positive rate of IGF- Ⅱ, IGF-l R and IGFBP-3 expression, and were significantly higher than the
other 3 groups (P<0.05). Colorectal adenoma tubular, mixed type, villous, different tissue types of IGF-Ⅱ , IGF-l R, the positive rate of
IGFBP-3 expression was gradually increased, villous adenoma was significantly higher than that of other two types (P<0.05). In 45 cases
of colorectal carcinoma, Dukes stage A, B period was significantly lower than that of C phase and D phase, and the difference was
significant (P<0.05).Conclusion:IGF-Ⅱ , IGF-l R, and IGFBP-3 may play a role in the process of colorectal adenoma occurrence and
progression to colorectal cancer, and have a certain clinical value in early diagnosis of colorectal cancer. |
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