| 许喆 杨洋 刘霞 满元元 郭晓东.右美托咪定对子宫肌瘤切除术患者全麻苏醒期应激反应的影响[J].,2014,14(24):4757-4759 |
| 右美托咪定对子宫肌瘤切除术患者全麻苏醒期应激反应的影响 |
| Effects of Dexmedetomidine on the Stress Reactions of IntravenousAnesthesia for Patients with Hysteromyomectomy |
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| DOI： |
| 中文关键词: 盐酸右美托咪定 子宫肌瘤切除术 应激反应 全凭静脉麻醉 |
| 英文关键词: Dexmedetomidine Hysteromyomectomy Stress reactions Total intravenous anesthesia |
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| 中文摘要: |
| 目的：探讨盐酸右美托咪定用于全凭静脉麻醉对子宫肌瘤切除术患者应激反应的影响。方法：选择我院收治的择期行子宫
肌瘤切除术患者60 例，随机分为观察组和对照组，每组30例。两组患者均采用全麻，其中观察组患者在麻醉诱导15 min 内静脉输注1 ug/kg 盐酸右美托咪定注射液，术中0.3-0.6 ug/(kg× h)维持；而对照组患者采用静脉输注0.9%的Nacl 溶液。分别于麻醉前、麻醉后及苏醒期测定并观察两组患者外周静脉血中TNF-alpha，IL-2 和IL-6 的浓度变化情况。结果：两组患者麻醉前TNF-α ，IL-2 和
IL-6 的浓度无显著性差异（P>0.05）。两组患者麻醉后及苏醒期TNF-alpha，IL-2 及IL-6 浓度均显著高于麻醉前，差异具有统计学意义（P<0.05）。观察组患者麻醉后及苏醒期TNF-alpha，IL-2 及IL-6 浓度均显著低于对照组，差异具有统计学意义（P<0.05）。结论：右美托
咪定用于全凭静脉麻醉对子宫肌瘤切除术患者血清TNF-alpha、IL-2 和IL-6 浓度具有调节作用，可缓解或降低手术引起的应激反应。 |
| 英文摘要: |
| Objective:To discuss the effects of dexmedetomidine on the stress reactions of intravenous anesthesia for patients with
the hysteromyomectomy.Methods:60 patients who were undergoing the hysteromyomectomy in our hospital were selected and randomly
divided into the observation group and the control group with 30 cases in each one. All the patients were taken the intravenous anesthesia.
The patients in the observation group were induced by the dexmedetomidine hydrochloride injection with 1 ug/kg in 15 min, and kept
in the operation with 0.3-0.6 ug/kg (h). While the patients in the control group were treated by the intravenous infusion with 0.9%Nacl.
Then the concentrations of TNF-alpha, IL-2 and IL-6 in the serumof patients before the anesthesia, after the anesthesia and the recovery were
detected and compared.Results:There was no statistically significant difference about the concentrations of TNF-alpha, IL-2 and IL-6 of patients
in the two groups before the anesthesia(P>0.05). The concentrations of TNF-alpha, IL-2 and IL-6 of patients after the anesthesia and in
the recovery were higher than before with statistically significant differences(P<0.05). The concentrations of TNF-alpha, IL-2 and IL-6 of patients
in the observation group were lower than those of the patients in the control group with statistically significant differences(P<0.05).Conclusion:It is indicated that the dexmedetomidine could alleviate or reduce the anesthetic stress reactions of patients with hysteromyomectomy
by means of regulating the concentrations of TNF-alpha, IL-2 and IL-6 in serum. |
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