| 何倩 李继红 余清平 周小青 刘旺华 李花 李新华 陈红艳.丹龙醒脑片对老年大鼠脑缺血再灌注后炎症反应的影响[J].,2014,14(26):5042-5044 |
| 丹龙醒脑片对老年大鼠脑缺血再灌注后炎症反应的影响 |
| Effect of Danlong Xingnao Tablet on Inflammatory Cascade Reaction afterCerebral Ischemia-Reperfusion in Elderly Rats |
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| DOI： |
| 中文关键词: 丹龙醒脑片 脑缺血再灌注 肿瘤坏死因子 白介素 |
| 英文关键词: Danlong Xingnao tablet Cerebral ischemia-reperfusion TNF IL |
| 基金项目:湖南省科技厅资助项目（2011FJ3141）；湖南中医药大学校青年科研课题项目（99820001-39）；
国家自然科学基金项目（81202632，8
1373702） |
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| 中文摘要: |
| 目的：从肿瘤坏死因子-a（TNF-a）和白介素（IL-1beta）表达变化揭示丹龙醒脑片抗老年脑缺血再灌注损伤的保护机制。方法：用大脑中动脉栓塞再通法建立脑缺血再灌注模型，将动物随机分为假手术组、模型组、丹龙醒脑片组和尼莫地平组，采用免疫组化法，观察TNF-a 和IL-1beta蛋白的表达。结果：丹龙醒脑片能显著减轻神经细胞的损伤；假手术组有一定量的TNF-a 和IL-1beta表达，缺血后TNF-a 和IL-1茁迅速增加，丹龙醒脑片组显著抑制TNF-a 和IL-1茁的表达，模型组和丹龙醒脑片组差异有统计学意义(P<0.01,P<0.05)。结论：丹龙醒脑片抗老年脑缺血再灌注损伤的保护机制与其抑制由缺血再灌注损伤诱导的TNF-a 和IL-1beta等表达有关。 |
| 英文摘要: |
| Objective:To investigate protective mechanism of Danlong Xingnao tablets through the change of expression of
TNF-a and IL-1beta after cerebral ischemia-reperfusion injury in elderly rats.Methods:divided into sham-operation group，model group,
Danlong Xingnao tablet group and nimodipine group. The expression of TNF-a and IL-1beta were detected by immunohistochemical
method and image analysis technique.Results:Danlong Xingnao tablets could markedly alleviate the injury of neurons. TNF-a and IL-1beta were expressed in sham-operation group, increased rapidly after cerebral ischemia-reperfusion, and significantly inhibited in Danlong
Xingnao tablets group. There was a significant difference between the model group and Danlong Xingnao tablet group (P<0.01, P<0.05).Conclusion:The brain-protective effect of Danlong Xingnao tablets is achieved possibly by inhibiting expression of TNF-a and IL-1beta induced by ischemia -reperfusion injury. |
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