| 王元 朱亚洲 种莹 陆士海 邱慧.乙肝患者血清的HBV-DNA 含量与ALT 水平的关系研究[J].,2014,14(29):5735-5737 |
| 乙肝患者血清的HBV-DNA 含量与ALT 水平的关系研究 |
| Research of the Relationship between SerumHBV-DNA Content and ALTLevel in Hepatitis B Patients |
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| DOI： |
| 中文关键词: 慢性乙型肝炎 乙型肝炎病毒DNA 丙氨酸氨基转移酶ALT 相关性研究 |
| 英文关键词: Chronic hepatitis b Hepatitis b virus DNA Alanine aminotransferase ALT Correlation study |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨和研究乙型肝炎患者乙型肝炎病毒(HBV)DNA复制水平与丙氨酸氨基转移酶(ALT)水平之间的关系，为临床中
乙肝患者的诊治提供参考。方法：对240 例慢性乙型肝炎患者采用荧光标记定量PCR 方法测定血清HBV-DNA 含量，采用全自动
生化分析仪测定血清ALT 水平，比较和分析HBV-DNA 含量与ALT 水平之间的关系。结果：慢性乙肝轻、中、重度患者的
HBV-DNA含量三组之间差异有统计学意义(p<0.01)，肝脏的损害程度与HBV-DNA 含量之间具有一定的关联，等级相关系数为
0.162（P=0.012）；ALT 水平也与HBV-DNA 载量之间存在关联，等级相关系数为0.371（P＜0.0001）。结论：肝损伤程度与
HBV-DNA含量有显著相关性；同时血清ALT水平与HBV-DNA含量呈正相关。检测血清中的HBV-DNA 含量和ALT 水平为指
导乙肝患者HBV 感染、复制、传染性的判断、治疗方案的选择和疗效评定提供有一定的依据。 |
| 英文摘要: |
| Objective:To discuss and research on the relationship between hepatitis b virus (HBV) DNA content and alanine
aminotransferase (ALT) levels of hepatitis b patients, providing reference for the clinical diagnosis and treatment of patients with chronic
hepatitis b.Methods:240 cases of patients with chronic hepatitis b were selected, fluorescence labeling quantitative polymerase chain
reaction (PCR) were used to detect the serum HBV DNA content, and automatic biochemical analyzer to determine serum ALT level of
the patients. The relationship between the HBV-DNA content and ALT level were compared and analyzed.Results:the difference of
HBV- DNA content among the three groups (Light, medium and severe chronic hepatitis b patients) all were statistically significant (P<0.
01), liver damage has a certain correlation with HBV-DNA content, and the rank correlation coefficient was 0.162(P = 0.012). ALT has a
positive correlation with HBV-DNA loads, the rank correlation coefficient was 0.371 (P<0.0001).Conclusion:Liver damage degree and
HBV-DNA content had a significant correlation; At the same time, serum ALT and HBV DNA content were positively correlated.
Detection of serum HBV DNA content and ALT level can provide guidance for the evaluation of HBV infection, replication and
infectivity, and choice of treatment for hepatitis b patients. |
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