| 杨进 马水根 徐朝军 尹晓清 尹邦良.食管鳞状细胞癌中HDGF、VEGF表达与微血管形成的关系[J].,2014,14(30):5956-5959 |
| 食管鳞状细胞癌中HDGF、VEGF表达与微血管形成的关系 |
| Relationship between the Expression of HDGF, VEGF and theAngiogenesis of Esophageal Squamous Cell Carcinoma |
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| DOI： |
| 中文关键词: 食管鳞状细胞癌 肝癌衍生生长因子 血管内皮生长因子 微血管密度 免疫组化法 |
| 英文关键词: Esophageal squamous cell carcinoma Hepatoma derived growth factor Vascular endothelial growth factor Microvessel
density Immunohistochemical method |
| 基金项目:湖南省自然科学基金项目（14JJ7060） |
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| 中文摘要: |
| 目的：研究食管鳞状细胞癌中肝癌衍生生长因子(HDGF)、血管内皮生长因子(VEGF)的表达及其与微血管形成的关系。方
法：通过免疫组化SABC 法检测和比较68 例食管鳞癌、20例切缘正常组织中HDGF、VEGF的表达和CD34 标记的微血管密度
(MVD)，分析HDGF和VEGF表达之间的关系及其与食管鳞癌患者临床病理因素和食管癌组织MVD 值的关系。结果：食管鳞癌
组织中HDGF(63.2％)和VEGF(72.1％)的阳性表达率均明显高于切缘正常粘膜组织(15.0％、20.0％)(P<0.05)，食管鳞癌组织和切
缘正常粘膜组织中的MVD 值分别为35.48± 5.75 和13.50± 2.1(P<0.05)。食管鳞癌组织HDGF 的阳性表达率仅与其临床分期明
显相关(P<0.05)，而VEGF的阳性表达率与其淋巴结转移、临床分期均显著相关(P<0.05)，二者在食管鳞癌组织中的表达呈显著正
相关(P<0.05)。食管鳞癌组织中HDGF、VEGF 阳性表达组MVD 值均明显高于HDGF、VEGF阴性表达组(P<0.05)。结论：HDGF可
能通过诱导VEGF的产生，从而促进血管生成，参与食管鳞癌的发生、发展及转移。 |
| 英文摘要: |
| Objective:To investigate the expression of hepatoma-derived growth factor (HDGF) and vascular endothelial growth
factor(VEGF) and their correlation with microangiogenesis in esophageal squamous cell carcinoma(SCC).Methods:Specimens from 68
cases of esophageal SCC tissues and 20 cases of the adjacent nomal esophageal tissues were examined by immunohistochemical
technique (SABC staining). The microvessel density (MVD) of tumor was evaluated using CD34 antibody as an endothelial marker with
the same technique. The relationship between the expression of HDGF and VEGF was analyzed, and their correlations with
clinicopathological characteristics and MVD values in patients with esophageal squamous cell carcinoma were discussed.Results:The
positive expression rates of HDGF (63.2%) and VEGF (72.1%) were significantly higher in esophageal SCC tissues than those in the
adjacent nomal esophageal tissues (15.0%) and (20.0%) respectively (P<0.05), and so did the MVD which was (35.48± 5.75) in
esophageal SCC and (13.50± 2.1) in the adjacent nomal esophageal tissues(P<0.05). The expression of HDGF was only correlated with
the clinical stage of esophageal SCC(P<0.05). The expression of VEGF had significant correlation with the clinical stage and lymph node
metastasis of esophageal SCC(P<0.05). The expression of HDGF were positively corelated with the expressions of VEGF(P<0.05). The
value of MVD in cases with positive expression of HDGF and VEGF were significantly higher than those cases with negative expression
of HDGF and VEGF (P<0.05).Conclusion:HDGF could promote the tumor angiogenesis through inducing the production of VEGF,
which was closely related to the occurrence, development and metastasis of esophageal SCC. |
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