| 周红凤 胡晓薇 栾英红 李迎君 陈桂云 刘文明 李凌 岳晓龙 和文杰 王雯 张波 吴瑾.MMP-2、Galectin-3、Cx43 与胃癌侵袭和转移的关系[J].,2014,14(33):6441-6445 |
| MMP-2、Galectin-3、Cx43 与胃癌侵袭和转移的关系 |
| The Relationship between Invasion and Metastasis of Gastric Cancer andMMP-2, Galectin-3 and Cx43 |
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| DOI： |
| 中文关键词: 胃癌 MMP-2 Galectin-3 Cx43 |
| 英文关键词: Gastric cancer MMP-2 Galectin-3 Cx43 |
| 基金项目:黑龙江省卫生厅科研课题（2007-406）；黑龙江省卫生厅科研课题（2007-397）；哈尔滨医科大学附属肿瘤医院院内基金（JJ2009-34） |
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| 中文摘要: |
| 目的：通过检测胃癌组织和癌旁组织中MMP-2、Galectin-3、Cx43 的表达情况，研究它们与胃癌发生、发展、侵袭及转移的关
系。方法：应用免疫组织化学（SP 法）法检测MMP-2、Galectin-3、Cx43 在胃癌组织和癌旁组织中的表达情况。结果：MMP-2 、
Galectin-3 在胃癌组织中的阳性表达均明显高于胃癌癌旁组织(P<0.05),并且均与浸润深度、淋巴结转移情况和临床分期明显相关
(P<0.05)；MMP-2 与胃癌的分化程度有关，而Galectin-3 与胃癌的分化程度无关；Cx43 在20例胃癌癌旁组织中的阳性表达率达
100%，在胃癌组织中阳性表达率为39.7%，在癌旁组织中的阳性表达明显高于胃癌组织，具有统计学意义(P<0.05)，Cx43 的表达
在胃癌的分化程度、浸润深度、淋巴结转移情况及临床分期方面存在显著差异，具有统计学意义(P<0.05)；MMP-2 阳性表达与
Cx43 阳性表达呈负相关(P=0.02，r= -0.292)，而与Galectin-3 阳性表达均为正相关(P=0.003，r= 0.344)。结论：在胃癌的发生、发展过
程中Galectin-3与MMP-2 有促进作用，而Cx43 有抑制作用，三者在胃癌的侵袭和转移中均发挥重要作用。 |
| 英文摘要: |
| Objective:To study the relationship between development, invasion and metastasis of gastric cancer and MMP-2,
Galectin-3 and Cx43 by detecting the expression of Cx43 MMP-2 and Galectin-3 in gastric cancer tissues and adjacent tissues.Methods:Immunohistochemistry (SP method) was used to detect the expression of MMP-2, Galectin-3, Cx43 in gastric cancer tissues and adjacent
tissues.Results:The positive expression level of MMP-2, Galectin-3 in gastric carcinoma were significantly higher than the adjacent
gastric cancer tissues (P<0.05), and were significantly associated with depth of invasion, lymph node metastasis and clinical stage
(P<0.05); The positive expression level of MMP-2 had related to the degree of differentiation of gastric cancer, but Galectin-3 had
nothing to do with the degree of differentiation of gastric cancer. In 20 cases, the positive expression rate of Cx43 was 100% in adjacent
gastric cancer tissues, and 39.7% in gastric cancer tissues. So the positive expression rate of Cx43 in adjacent gastric cancer tissues was
statistically significantly higher than in gastric cancer, depth of invasion, lymph node metastasis and clinical staging had different effect
on the positive expression of Cx43 (P<0.05); The positive expression level of MMP-2 and Cx43 were negatively correlated (P= 0.02, r=
-0.292), and the positive expression level of MMP-2 and Galectin-3 were positively correlated (P = 0.003, r = 0.344).Conclusion:Galectin-3 and MMP-2 promote the development of gastric cancer, Cx43 inhibit it. All the three play an important role in the invasion
and metastasis of gastric cancer. |
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