| 徐正平 董春雷 夏野 蒋煜 陈相健.高敏肌钙蛋白预测急性冠脉综合征的价值分析[J].,2014,14(35):6886-6888 |
| 高敏肌钙蛋白预测急性冠脉综合征的价值分析 |
| Value Analysis of High Sensitivity Troponin to Predict AcuteCoronary Syndrome |
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| DOI： |
| 中文关键词: 高敏肌钙蛋白 急性冠脉综合征 早期诊断 |
| 英文关键词: Hs-cTnI Acute coronary syndrome Early diagnosis |
| 基金项目:国家自 然科学基金项目（ 81 170220） |
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| 中文摘要: |
| 目的： 研究早期检测高敏肌钙蛋白对预测及诊断急性冠脉综合征的价值。 方法： 以 2012 年 1 月 至 2014 年 07 月 于我院就诊
的 82 例疑似急性冠脉综合征患者为研究对象， 采集血液标本， 均分为 两组，一组行血清常规肌钙蛋白 T（ cTnT）检测， 结果归入对
照组；一组行血清高敏肌钙蛋白（ hs-cTnI）检测， 结果归入观察组。 同 时行心肌酶谱及心电图检查， 以其动态演变为金标准，评价两
组敏感度、特异度，绘制 ROC 曲线。 结果： 金标准提示共 64 例阳性患者。 观察组检测 hs-cTnI 阳性 62 例 ，敏感度 92.2 %（ 59/64），
特异度 88.9 %（ 16/18）；对照组检查 cTnT 阳性 59 例 ，敏感度 79.7 %（ 51 /64）， 特异度 55.6 %（ 10/18）， 观察组 ROC 曲线优于对照组
（ P=0.000）。 健康人群肌钙蛋白 含量显著性低于急性冠脉综合征患者， 差异具备统计学意义（ P＜ 0.05）。 结论： hs-cTnI 检测有助于
预测急性冠脉综合征， 其诊断敏感度及特异度均较高， 可满足现阶段诊治需求。 |
| 英文摘要: |
| Objective:To Study the value of early detection of high sensitivity troponin’ s in prediction and diagnosis of acute
coronary syndrome.Methods:82 cases of patients with suspected acute coronary syndrome in our hospital from January 201 2 to
December 2014 were selected as the research objects. The blood specimens were collected, and the normal serum troponin T (cTnT) was
tested, then the results were placed in control group; while the serum high sensitivity troponin (hs-cTnI) was tested, and the results was
set in observation group. At the same time, electrocardiogram (ecg) and myocardial enzyme spectrum examination were conducted, and
its dynamic evolution was used as the gold standard to evaluate the sensitivity and specific degrees of the two groups were evaluated and
to make ROC curve.Results:The gold standard suggested that a total of 64 patients were positive. In the observation group, 62 cases of
hs-cTnI were detected positive, and the sensitivity was 92.2 % (59/64), the specificity was 88.9 % (1 6/1 8); while in the control group, 59
cases of cTnT were positive, and the sensitivity was 79.7 % (51/64), and the specificity was 55.6 % (1 0/18). The ROC curve of
observation group was better than that of the control group (P=0.000). The troponin level of healthy people was significantly lower than
that of patients with acute coronary syndrome, and the differences are statistically different (P<0.05).Conclusion:Hs-cTnI detection can
contribute to predict acute coronary syndrome which has a high diagnostic sensitivity and specificity, and can meet the demand of current
diagnosis and treatment. |
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