| 赵智宏 王胜发 姜久仰 高大登 王巨 常浩 曲俊峰.Pokemon 在小细胞肺癌中的表达及临床意义[J].,2014,14(36):7147-7150 |
| Pokemon 在小细胞肺癌中的表达及临床意义 |
| Expression and Clinical Significances of Pokemon in Small Cell LungCancer |
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| DOI： |
| 中文关键词: 小细胞肺癌 Pokemon 表达 预后 |
| 英文关键词: Small cell lung cancer Pokemon Expression Prognosis |
| 基金项目:黑龙江省卫生厅基金项目（2011-026） |
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| 中文摘要: |
| 目的：检测Pokemon 在小细胞肺癌(SCLC)中的表达情况，并探讨其在SCLC 发生、发展中的作用及临床意义。方法：应用SP
免疫组化方法检测Pokemon 在52 例SCLC 肿瘤组织及20 例病灶旁正常组织中的表达。结果：Pokemon 在正常肺组织中不表达，
52 例SCLC组织中，35 例呈阳性表达，占67.3%。Pokemon 的表达与SCLC 患者的性别、年龄、吸烟、淋巴结转移情况均无关(P>0.
05)，而与TNM 分期显著相关(P＜0.05)。Pokemon 阳性表达者生存期明显短于阴性表达者，二者比较差异有统计学意义(P＜0.05)。
单因素分析结果显示TNM 分期、Pokemon的表达与SCLC 患者的预后相关；多因素分析结果显示仅Pokemon 的表达与SCLC 患
者的预后显著相关(P=0.013)。结论：Pokemon 在SCLC 组织中呈高表达，预示SCLC 患者的预后较差，Pokemon表达可能作为
SCLC的独立预后预测因素。 |
| 英文摘要: |
| Objective:To study the expression and clinical significances of Pokemon gene in the small cell lung cancer (SCLC).Methods:Immunohistochemistry was applied to detect the expression of Pokemon protein in 52 cases of SCLC and 20 cases of
tumor-surrounding normal lung tissues.Results:Pokemon didn't express in normal lung tissues and expressed in 35 cases (67.3%) of 52
cases of SCLC. The expression of Pokemon gene had no correlation with the sex, age, smoking, or lymph node metastasis of the patients
with SCLC(P＞0.05), but it was obviously related to the TNM stages(P＜0.05). The survival time of patients with positive expression of
Pokemon was significantly shorter than those with negative expression of Pokemon(P<0.05). Univariate analysis showed that TNMstage
and Pokemon expression were correlated with the prognosis of SCLC patients, while multivariate analysis showed the expression of
Pokemon was the single factor related to the prognosis of SCLC patients.(P=0.013).Conclusion:High expression of Pokemon gene was
found in SCLC, which indicated the poor prognosis of SCLC patients. The expression of Pokemon may be used as an independent
prognostic factor of SCLC. |
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