| 洪景芳 丁学华 王守森 刘峥 郑兆聪.DDR1 在人垂体腺瘤组织中的表达及其临床意义[J].,2015,15(4):723-726 |
| DDR1 在人垂体腺瘤组织中的表达及其临床意义 |
| Expression of DDR1 in Pituitary Adenomas and its Clinical Significances |
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| DOI： |
| 中文关键词: 垂体腺瘤 盘状结构域受体1 表达 临床意义 |
| 英文关键词: Pituitary adenoma DDR1 Expression Clinical significance |
| 基金项目:福建省自然科学基金青年创新项目（2011J05091） |
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| 中文摘要: |
| 目的：检测盘状结构域受体1(DDR1)在垂体腺瘤中的蛋白表达水平并探讨其临床意义。方法：收集81 例手术切除的垂体腺
瘤和5 例正常垂体前叶组织标本及其临床资料，应用免疫组化SP法检测和比较其DDR1蛋白的表达情况，并分析垂体腺瘤组织
中DDR1 蛋白的表达与患者临床及病理特征的相关性。结果：垂体腺瘤组织中DDR1的阳性表达率为64.2%(52/81 例)；侵袭性垂
体腺瘤组织中DDR1 蛋白的阳性表达率显著高于非侵袭性垂体腺瘤(x2=16.40，P=0.000)；功能性垂体腺瘤组织中DDR1 蛋白的阳
性表达率显著高于无功能性垂体腺瘤(x2=18.06，P=0.000)；直径≥ 10 mm垂体腺瘤组织中DDR1蛋白的阳性表达率显著高于直
径＜10 mm 的垂体腺瘤(x2=11.68，P=0.003)。结论：DDR1的表达与垂体腺瘤的侵袭性、内分泌类型和肿瘤大小有关，可能在垂体腺
瘤发病机制中起重要作用。 |
| 英文摘要: |
| Objective:To investigate the protein expression of Discoidin Domain Receptor 1(DDR1) in pituitary adenomas and its
clinical significances.Methods:The tissue specimens and clinical data of 81 cases of pituitary adenomas and 5 cases of normal pituitary
tissues were obtained. Immunohistochemistry was used to detect and compare the expression of DDR1. The correlation of DDR1 protein
expression with the clinical and pathological characteristics of pituitary adenomas patients was analyzed.Results:The positive expression
rate of DDR1 protein in pituitary adenomas was 64.2%(52/81). The positive expression rate of DDR1 protein in invasive pituitary adenomas
was significantly higher than that in the noninvasive pituitary adenomas(x2＝16.40, P=0.000). The positive expression rate of DDR1
protein in functional pituitary adenomas was significantly higher than that in nonfunctional pituitary adenomas(x2＝18.06, P=0.000). The
positive expression rate of DDR1 protein in pituitary adenomas with diameter larger than 10mm was significantly higher than that with
diameter smaller than 10 mm (x2=11.68, P=0.003).Conclusion:The expression of DDR1 was significantly correlated with the invasiveness,
endocrine subtypes and diameter of pituitary adenomas, DDR1 could play an important role in the pathogenesis of pituitary adenomas. |
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