| Objective:To investigate the clinical characteristics and influencing factors of non-small cell lung cancer with hypercoagulability.Methods:A total of 195 cases of non-small cell lung cancer patients with hypercoagulability admitted in Beijing Military
Region Oncology from March 2011 and Nov 2012 were investigated and the relationship between clinical factors, including age, gender,
pathological, ECOG performance, central venous catheters, chemotherapy, radiotherapy, clinical stage as well as merger disease, and hypercoagulability of non-small cell lung cancer patients were analyzed.Results:Among 195 non small cell lung cancer patients, 170
(85%) cases had abnormal hypercoagulabe indicators, PLT elevated were found in 42 patients (21.5%), FIB increased in 78 cases (40%),
TT extended in 1 2 cases (6.2%), PT shortened in 45 cases (23.1 %) again, D-D increased in 60 cases (30.8%), and APTT reduced in 15
cases (7.7%). No significant difference was observed among the age, radiotherapy, central venous catheters and hypercoagulable state of
NSCLC patients (P>0.05). But the male group had higher level of TT than female group, the Adenocarcinoma group had higher level of
FIB than Squamous and others group, ECOG≤ 2 group had higher level of PT and FIB than ECOG>2 groups,the level of APTT and PT
of Chemotherapy group were lower than those of non-chemotherapy group, stage Ⅲ ~ Ⅳ had higher levels of FIB than those in stageⅠ ~
Ⅱ NSCLC patients, the TT, PT levels of non-complications group were lower than those of each complications group (P<0.05).Conclusion:Patients with NSCLC were susceptible to hypercoagulative state, which may be related with the gender, ECOG performance,
chemotherapy, clinical stage and merger disease. How to use the anticoagulant therapy and improve the quality of life of NSCLC should
be further researched. |
