| 王世寿 蔺景双 崔丽华 冯 涛 郝兴亮.经支气管镜氩离子凝固术治疗伴有咯血的晚期中心型肺癌的临床观察[J].,2015,15(5):918-921 |
| 经支气管镜氩离子凝固术治疗伴有咯血的晚期中心型肺癌的临床观察 |
| Clinical Effect of Argon Plasma Coagulation by Bronchoscope Interventionin Treatment of 60 Cases of Elderly Patients with Central Lung CancerCombined with Hemoptysis |
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| DOI： |
| 中文关键词: 经支气管镜氩离 子凝固 术 晚期中心型肺癌 咯血 疗 效 |
| 英文关键词: Argon plasma coagulation by bronchoscope intervention Advanced central lung cancer HAemoptysis Effect |
| 基金项目: |
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| 中文摘要: |
| 目的： 探讨经支气管镜氩离 子凝固术治疗伴有咯血的晚期中心型肺癌的疗效。 方法： 选取 2011 年 12 月 -2013 年 6 月 期间我
院收治的晚期中心型肺癌咯血的患者 60 例 ， 将其随机分为观察组（ 30 例）和对照组（ 30 例）， 观察组给予经支气管镜氩离 子凝固
术联合全身化疗，对照组给予经支气管镜介入局部用 药联合全身化疗，对比两组患者治疗 后的临床疗 效、 24h 动脉血气分析、肺功
能、止血有效率及治疗后 3 天、 3~7 天， 7 天复发率以及总复发率和不良反应情况。 结果： 治疗 后两组患者的临床症状均得到一定
的改善， 观察组患者的临床有效率为 80.0%（ 24/30）显著高于对照组的 56.7%（ 1 7/30）， 差异具有统计学意义（ P<0.05）； 观察组患者
在发热、呼吸困难、咳嗽、胸痛及咯血等方面的症状缓解率均显著高于对照组， 比较差异均有统计学意义（均 P<0.05）； 治疗 后观察
组肺功能和 24h 动脉血气分析各项指标均显著优于治疗 前， 观察组患者的的以上指标均显著优于对照组， 差异均有统计学意义
（均 P<0.05）； 治疗后观察组患者的止血有效率为 1 00%， 显著高于对照组的 56.7%（ 17/30）， 且观察组患者术后 3 天、 3~7 天， 7 天复
发率以及总复发率均小于对照组， 两组止血有效率和总复发率比较差异均有统计学意义（均 P<0.05）； 观察组患者不良反应的发
生率为 10.0%，对照组为 13.3%， 两组相比无显著差异（ P>0.05）。 结论： 经支气管镜氩离 子凝固术联合全身化疗 治疗老年晚期中心
型肺癌咯血具有较好的临床疗效， 止血迅速有效， 且复发率低， 能够缓解呼吸道阻塞症状， 改善呼吸功能， 是一种不错的选择， 值
得在临床普遍推广与 应用 。 |
| 英文摘要: |
| Objective:To investigate the clinical effect of argon plasma coagulation by bronchoscope intervention in treatment of
elderly patients with central lung cancer combined with hemoptysis.Methods:60 cases of late central type lung cancer patients were selected from our hospital during the period from December 2011 to June 2012. Which were randomly divided into the observation group
(30cases) and the control group (30 cases). The patients of the observation group were treated with argon plasma coagulation by bronchoscope intervention combined with systemic chemotherapy, the control group were treated with topic bronchoscopic intervention combined with systemic chemotherapy. The clinical efficacy of the two groups, 24h arterial blood gas analysis and pulmonary function, the
record bleeding rate after 3 days, 3 to 7 days, 7 days and the total recurrence rate after treatment and the adverse reactions after treatment
were compared.Results:After treatment, the clinical symptoms of the patients had certain improvement. The clinical effective rate of the
observation group was 80.0% (24/30), significantly higher than 56.7% (17/30) of the control group, the difference was statistically significant (P<0.05); The remission rates of fever, chest tightness and dyspnea ,cough, chest pain, hemoptysis in the observation group after
treatment were significantly higher than that in the control group, the difference was statistically significant (P<0.05); After treatment, the
24h arterial blood gas analysis and pulmonary function were all better than before treatment, and the above indicates of the observation
group were significantly better than those of the control group, the difference was statistically significant (P<0.05); After treatment, the
hemostatic effective rate of the observation group was 100%,significantly higher than 56.7% (1 7/30) of the control group. The record
bleeding rate after 3 days, 3 to 7 days, 7 days and the total recurrence rate of the observation group were significantly less than that of the
control group after treatment, the difference of the hemostatic effective rate and total recurrence rate was statistically significant between
two groups(P<0.05); The adverse reaction rate of the observation group was 1 0.0% and the adverse reaction rate of the control group was
13.3%, the difference was not statistically significant (P<0.05).Conclusion:The treatment of hemoptysis in central lung cancer of elderly patients with argon plasma coagulation by bronchoscope intervention combined with systemic chemotherapy has better efficacy. The recurrence rate was low and it can significantly alleviate the symptoms of obstruction and improve respiratory function. It is a good choice
and is a safe and effective treatment method; it is worth to be popularized in clinical application. |
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