| 虞蕾楠 姚广裕 胡晓磊 陈路嘉 叶长生 杨学习.雌激素受体阳性乳腺癌中mTOR 蛋白的表达及与内分泌辅助治疗预后的关系[J].,2015,15(8):1418-1420 |
| 雌激素受体阳性乳腺癌中mTOR 蛋白的表达及与内分泌辅助治疗预后的关系 |
| Expression of mTOR Protein in Estrogen Receptor-Positive Breast Cancerand its Relationship with Prognosis of Endocrine Adjuvant Therapy |
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| DOI： |
| 中文关键词: 乳腺癌 雌激素受体 mTOR蛋白 内分泌 预后 |
| 英文关键词: Breast cancer Estrogen receptor mTOR protein Endocrine Prognosis |
| 基金项目: |
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| 中文摘要: |
| 目的：研究雌激素受体阳性乳腺癌中mTOR 蛋白的表达以及与内分泌辅助治疗预后的关系。方法：选取2010 年6 月到2011
年8 月我院收治的雌激素受体阳性乳腺癌且接受内分泌辅助治疗的患者110 例，应用免疫组化法检测患者乳腺癌组织中的
mTOR蛋白的表达，观察其与临床特征和预后的关系。结果：mTOR 蛋白表达阳性者68 例，mTOR蛋白表达阴性者42 例，mTOR
蛋白表达阳性者存在较多的组织学特征；mTOR 蛋白表达阴性者无病中位生存期为（56.8± 1.1）个月，显著优于mTOR 蛋白表达
阳性者的（32.8± 2.1）个月，比较差异具有统计学意义（P＜0.05）；多因素分析显示，mTOR 蛋白表达阳性者出现肿瘤复发转移的风
险是mTOR 蛋白表达阴性者的3.21 倍，且是影响预后的独立性影响因子。结论：mTOR蛋白的表达阳性是雌激素受体阳性乳腺
癌复发转移的独立因素，在临床上可以联合mTOR抑制剂来治疗。 |
| 英文摘要: |
| Objective:To study the expression of mtor protein in estrogen receptor-positive breast cancer patients and its
relationship with prognosis of endocrine adjuvant therapy.Methods:A total of 110 patients with estrogen receptor-positive breast cancer,
who were admitted to Southern Hospital of Southern Medical University from June 2010 to August 2011, were selected and the mTOR
protein expressions in their breast tissues were examined by immunohistochemistry method,and observed its relationship with clinical
features and prognosis.Results:The expression of mTOR protein was positive in 68 cases;negative, in 42 cases. The patients with mTOR
protein expression positive had more positive histologic features. The median disease-free survival time of mTOR protein expression
negative patients was (56.8± 1.1) months, significantly better than (32.8 ± 2.1) months in mTOR protein positive patients, the difference
was statistically significant (P <0.05). Multivariate analysis showed that the risk of tumor recurrence and metastasis of mTOR protein
expression positive patients ,which was the independent influencing factor of prognosis, was 3.21 times that of mTOR protein expression
negative patients.Conclusion:The mTOR protein expression positive is the independence factor of recurrence and metastasis of patients
with estrogen receptor-positive breast cancer,which can be treated by being combined with mTOR inhibitor clinically. |
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