| 于艳红 许杰 李文彬 李红粉 温世荣.Tau 蛋白磷酸化在阿尔茨海默病中所处的地位[J].,2015,15(8):1573-1576 |
| Tau 蛋白磷酸化在阿尔茨海默病中所处的地位 |
| Tau Protein Phosphorylation in Alzheimer's disease |
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| DOI： |
| 中文关键词: 阿尔茨海默病 tau 蛋白 蛋白激酶 磷酸酯酶 |
| 英文关键词: Alzheimer's disease (AD) Tau Protein kinases Phosphatases |
| 基金项目: |
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| 中文摘要: |
| 阿尔茨海默病(Alzheimer's disease, AD)是一种老年人常见的神经系统退行性疾病，是痴呆最常见的病因。AD 患者越来越多，给家属及社会带来严重负担造成了巨大的家庭和社会负担，这就迫使我们进一步探讨AD发病机制。在AD的众多发病机制中，tau 蛋白假说倍受青睐。在蛋白磷酸酯酶2A（protein phosphatase 2A，PP2A）、糖原合酶激酶-3beta( glycogen synthase kinase-3beta，GSK-3beta)、细胞周期依赖性蛋白激酶-5( cyclin-dependent kinase 5，CDK-5)和Bcl-2 等蛋白酶及调节蛋白作用下，微管相关蛋白tau
蛋白以其异常磷酸化结构或是形成二聚体、寡聚体和神经原纤维缠结等形式，参与到AD 的病理过程。Tau 蛋白及其相关结构，可
能启动或促进了AD的凋亡，亦可能抑制了急性凋亡却促进了慢性的神经细胞变性。揭开这一谜底，可能揭开AD病理改变的神
秘面纱。 |
| 英文摘要: |
| Alzheimer's disease (AD)is a progressive neurodegenera-tire disease and the most common form of dementia．There
is the heavy burden to families and society with the growing number of AD patients, which forces us further to explore the mechanism of
Alzheimer's disease (AD). Among the pathogenesis of AD, the tau protein hypothesis is more popular. The microtubule associated
protein -tau, with its abnormal phosphorylation structure by forming dimers, oligomers and neurofibrillary tangles, involves in the
pathological process of AD, under the interaction of proteases and regulatory proteins including protein phosphatase 2A (PP2A),
glycogen synthase kinase 3-beta(GSK - 3beta), cell cycle dependent protein kinase5 (CDK - 5) and the Bcl - 2.Tau and its related structure
may either start or promote the apoptosis of AD or inhibit the acute apoptosis but contribute to the chronic nerve cell degeneration.
Uncover the mystery, may uncover the mysteries of pathological changes of AD. |
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