| 曲艺欣 王峰 姜成功 陈敬丽 刘宏涛 苏颖.三氧化二砷对视网膜色素上皮细胞增殖的影响[J].,2015,15(8):1598-1600 |
| 三氧化二砷对视网膜色素上皮细胞增殖的影响 |
| Arsenic Trioxide Effects on Retinal Pigment Epithelial Cell Proliferation |
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| DOI： |
| 中文关键词: 三氧化二砷 视网膜色素上皮细胞 细胞增殖 综述 |
| 英文关键词: Arsenic Trioxide Retinal Pigment Epithelial Cells Cell Proliferation Review |
| 基金项目:国家自然科学基金项目（81100659） |
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| 中文摘要: |
| 视网膜色素上皮细胞(retinal pigment epithelial cell，RPE)在维护视网膜正常生理功能方面具有极其重要的作用。研究发现，
视网膜色素上皮细胞是增殖性玻璃体视网膜疾病（proliferative vitreous retinopathy，PVR)发生发展的主要细胞，而其增殖与细胞内
调控信息失调密切相关。多项研究成果表明，三氧化二砷(As2O3)已经被用于医药几千年。其在白血病治疗的使用早在一个世纪以
前就有所描述。As2O3在医学上的作用有着悠久的历史。然而，在最近的几个世纪它几乎被遗忘在西方医学。三氧化二砷在白血
病、肿瘤的基础研究与临床治疗中已取得较大进展，引起广泛关注，但在眼科领域的研究才刚刚起步.增殖性视网膜疾病的发病日
趋严重，已经成为全球性的重大负担，此病所导致的眼部并发症严重影响患者视功能及生活质量，因此，有必要就三氧化二砷对
视网膜色素上皮细胞增殖的作用进行综述，以期为眼科疾病的防治研工作提供新的思路和策略。 |
| 英文摘要: |
| Retinal pigment epithelial cells (RPE) have an extremely vital role in maintaining normal retinal physiological
function. Researches have found that retinal pigment epithelial cells are the main cells for the development of proliferative vitreous
retinopathy (PVR). Anumber of studies have demonstrated that arsenic trioxide (As2O3) has been applied in medicine for thousands of
years. Its use in leukemia treatment are described as early as a century ago. However, in recent centuries, it is almost forgotten in
western medicine. Although the basic and clinical research on arsenic trioxide in leukemia and cancer has made great progress and get
extensive attention, the research in the eye field has just started. Hyperplastic diseases of retina disease has become increasingly
serious. It has become a major global burden. The ocular complications it caused seriously affect the patient's visual function and quality
of life. Therefore, it is necessary to review the proliferation role of arsenic trioxide on the retinal pigment epithelial cell so as to provide
new ideas and strategies for the prevention and control of the eye disease. |
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