| 诺敏 鹿亚平 张海龙 冯立新 郭晓东.老年社区获得性肺炎患者TNF-alpha和sTREM-1 的表达及临床意义[J].,2015,15(9):1695-1697 |
| 老年社区获得性肺炎患者TNF-alpha和sTREM-1 的表达及临床意义 |
| Expression of TNF-alpha and sTREM-1 in Patients with Community-acquiredPneumonia and its Clinical Significance |
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| DOI： |
| 中文关键词: 社区获得性肺炎 CAP TNF-alpha sTREM-1 |
| 英文关键词: Community-acquired pneumonia CAP TNF-alpha sTREM-1 |
| 基金项目:国家自然科学基金青年科学基金项目（30901795） |
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| 中文摘要: |
| 目的：探讨老年社区获得性肺炎患者TNF-alpha和sTREM-1 表达水平及其临床意义。方法：从我院选择48 例社区获得性肺炎患者为CAP 组（重症组和普通组），另选取对照组48 例。收集两组患者的血浆及BALF，分别收集重症组患者住院后1 天、4 天的血浆和BALF，对比各组sTREM-1 和TNF- alpha的表达水平。结果：对照组TNF-alpha和sTREM-1 的表达水平均低于CAP 组（P＜0.05）；重症患者的TNF-alpha和sTREM-1 表达水平高于普通组和健康对照组（P＜0.05）。重症患者TNF-alpha表达水平与对照组无显著
差异（P＞ 0.05），而sTREM-1 表达高于对照组，差异有统计学意义（P＜0.05）。结论：TNF-alpha和sTREM-1 表达水平与CAP的发病
过程密切相关，其表达水平与CAP 的严重程度呈正相关。 |
| 英文摘要: |
| Objective:To explore the clinical significance of the expression of TNF-alpha and STREM-1 in elderly patients with
community-acquired pneumonia (CAP).Methods:48 CAP patients from Department of Respiratory Medicine in our hospital were
enrolled based on the selection criteria and divided into severe group and ordinary group. The plasma and bronchoalveolar lavage fluid
(BALF) of CAP group, control group, severe CAP patients’first day and fourth day after treatment in hospital were collected. The
expression levels of sTREM-1 and TNF-alpha of each group were compared.Results:TNF-琢and STREM-1 levels of control group were
lower than those of CAP group with statistically significant differences (P<0.05). TNF-alpha and STREM-1 levels of severe CAP patients
were higher than ordinary CAP patients and healthy controls (P＜0.05). No obvious differences existed between TNF-alpha level of severe
CAP patients and lung cancer controls (P>0.05). Significant differences existed between sTREM-1 level of severe CAP patients and lung
cancer controls (P<0.05).Conclusion:The expression levels of TNF-alpha and sTREM-1 were associated with pathogenesis and progression
and severity of CAP. |
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