| 杨路加 张树卓 王显望 王沛齐 张宏.HCN2 阳离子通道：缓解疼痛的新靶点[J].,2015,15(9):1781-1784 |
| HCN2 阳离子通道：缓解疼痛的新靶点 |
| Role of the HCN2 Channel:A Key Target to Ameliorate the Pain |
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| DOI： |
| 中文关键词: 超极化激活的环核苷酸门控通道 炎性痛 神经病理性痛 ZD7288 |
| 英文关键词: Hyperpolarization-activated cyclic nucleotide-modulated ion channel Inflammatory pain Neuropathic pain ZD7288 |
| 基金项目: |
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| 中文摘要: |
| 疼痛长期困扰人类健康，其发病机制纷繁复杂，究竟谁在其中扮演了重要的作用是目前亟待解决的重大问题。随着对疼痛
研究的不断深入，超极化激活的环核苷酸门控通道逐渐引起广泛关注。在炎性痛和神经病理性痛过程中，它都扮演了至关重要的
作用，其数目改变和开放频率增加都参与介导了疼痛部位的异常放电，成为诱发疼痛的开关。在给与阻断剂或敲除通道2亚型
后，能明显缓解炎性痛和神经病理性痛的不良反应，成为可以缓解疼痛发生的新靶点。超极化激活的环核苷酸门控通道在机体分
布广泛，参与多种重要生理功能的调节，但目前还没有针对该门控通道某种亚型的特异性阻断剂。在今后，也许超极化激活的环
核苷酸门控通道会成为临床治疗疼痛的新靶点，该通道的特异性药物也将为广大患者带来新的福音。 |
| 英文摘要: |
| All kinds of pain bother us. However, the underlying mechanisms remain unclear. There seem like many elements involve
in the happening of the pain and it is very important to explore who trigger the procedure. With the in-depth of research, hyperpolarization-
activated cyclic nucleotide-modulated ion channel (HCN) gradually emerges. In inflammatory pain and neuropathic pain, HCN
channel plays a crucial role in modulating abnormal discharges, which mediate the conduction of pain. By using HCN block-out mice
and antagonist ZD7288, inflammatory pain and neuropathic pain all partial relieved in some degrees. Base on previous researches, HCN
channel will possibly become a novel target to ameliorate the pain. Since now, there is still no specific antagonist. However, in the future,
high selective medicine may offer benefit to those patients who suffer frompain. |
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