| 桑勉 张鹏 聂波 李燕 徐荣谦.茵陈蒿汤加减方对哮喘大鼠模型气道TGF-beta1 的干预作用[J].,2015,15(11):2001-2004 |
| 茵陈蒿汤加减方对哮喘大鼠模型气道TGF-beta1 的干预作用 |
| Intervention Effects Yinchenhao Decoction on TGF-beta 1 of Airwayin Asthmatic Rat Model |
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| DOI： |
| 中文关键词: 茵陈蒿汤加减方 哮喘 气道重塑 血清TGF-beta1 |
| 英文关键词: Yinchenhao Decoction Asthma Airway remodeling TGF-beta1 |
| 基金项目:高等学校博士学科点专项科研基金项目（20100013110013）；北京中医药大学自主创新课题（JYBZZ-JS059） |
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| 中文摘要: |
| 目的：探讨茵陈蒿汤加减方对哮喘气道转化生长因子-beta1（TGF-beta1）的干预机制。方法：制备大鼠哮喘模型，模型动物随机分
为四个组：模型组、西药（地塞米松）组、中药组，空白对照组，每组10 只大鼠。从第17 天起开始给予相应药液灌胃，西药组给予地
塞米松1 g/kg，中药组给予茵陈蒿汤加减方配方颗粒溶液（浓度0.5 g/mL）5 mL/kg，每日1 次。空白对照组和模型组分别以等量的
生理盐水灌胃，每周按照大鼠体重调整1 次。连续给药干预4 周，检测血清中TGF-beta1 含量并进行比较分析。结果：中药组与西药
组均可降低TGF-beta1 的含量，与模型组比较有显著性差异(P<0.01)，中药组与西药组效果相当（P>0.05）。结论：茵陈蒿汤加减方能
通过有效地减低大鼠血清中TGF-beta1 的含量，从而阻断气道重塑的发生，达到预防和缓解哮喘的治疗目的。 |
| 英文摘要: |
| Objective:To investigate the intervention mechanismof Artemisia Decoction on transforming growth factor-beta1 (TGF-
beta1) of asthma airway.Methods:The rat model of asthma was prepared, then the animals were randomly divided into four groups: model
group, western medicine group (dexamethasone), Chinese medicine group, blank control group, 10 rats in each group. Except blank
control group and model group, other groups were administered the corresponding by gavage from the 17th day once a day. The rats in
the blank control group and model group were gavaged with normal saline, which was adjusted once a week according to the body
weight of rats. After continuous administration for 4 weeks, the serum levels of TGF-beta1content were detected and comparatively
analyzed.Results:The traditional Chinese medicine group and Western medicine group can reduce the content of TGF-beta1 with
significant difference compared with the model group (P<0.01), while Chinese medicine group and Western medicine group had an
equivalent effect (P>0.05).Conclusion:Yinchenhao Decoction can effectively reduce content of TGF-beta1 in serum of rats, thereby block
the occurrence of airway remodeling, then contribute to prevent and relieve asthma. |
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