| 刘泽民 马远征 李大伟 谢聪钦 黄新 刘志 刘飞.TNF-alpha，IFN-r，TGF-beta及IL-10 在骨关节结核中的表达及意义[J].,2015,15(11):2031-2033 |
| TNF-alpha，IFN-r，TGF-beta及IL-10 在骨关节结核中的表达及意义 |
| Expressions and Significance of TNF-alpha, IFN-r, TGF-beta and IL-10on the Tuberculosis of Bone |
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| DOI： |
| 中文关键词: 骨结核 转化生长因子-beta 肿瘤坏死因子-alpha 干扰素-r 白介素-10 |
| 英文关键词: Tuberculosis of Bone TGF-beta TNF-alpha IFN-r IL-10 |
| 基金项目:国家自然科学基金项目（81071454）；全军青年培育项目（4241287K）；309医院重点课题（2013ZD-003） |
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| 中文摘要: |
| 目的：探讨转化生长因子（TGF-beta）、肿瘤坏死因子（TNF-alpha）、干扰素- r（IFN-r）及白介素-10（IL-10）在骨关节结核组织中的
表达及其对骨质骨量的影响。方法：选择2012 年6 月-2014 年6 月我院收治的骨关节结核患者50 例，应用免疫组化法检测患者
结核中心病灶TGF-beta、TNF-alpha、IFN-r及IL-10 的表达水平。结果：TNF-alpha、IFN-r、TGF-beta及IL-10 在结核组织中呈不同程度的阳性
表达（P<0.05）。TNF-alpha和IFN-r在增生性病变中的表达高于干酪性病变，TGF-茁和IL-10 在干酪性病变中的表达高于增生性病变
（P<0.05）。增生性病变中，IFN-r在坏死性结核肉芽肿中的表达低于非坏死性肉芽肿（P<0.05），TNF-琢、TGF-beta及IL-10 表达无明
显差异（P>0.05）。干酪性病变中，TNF-琢在非坏死性结核肉芽肿中的表达高于坏死性肉芽肿，TGF-茁在坏死性结核肉芽肿中的表
达高于非坏死性肉芽肿（P<0.05），IFN-r和IL-10 表达无明显差异（P>0.05）。与正常骨组织细胞数相比，增生性病变与干酪性病变
组织的成骨细胞数低，破骨细胞数高（P<0.05）。结论：TGF-beta、TNF-alpha、IFN-r及IL-10 在骨关节结核组织中存在不同程度的表达，对
病情的发生发展及骨质骨量具有重要影响。 |
| 英文摘要: |
| Objective:To investigate the expressions and significance of TGF-beta, TNF-alpha, IFN-r and IL-10 in the tuberculosis of
bone.Methods:50 cases with spinal tuberculosis who were treated in our hospital from June 2012 to June 2014 were selected. Then the
expressions of TGF-beta, TNF-alpha, IFN-r and IL-10 in the tuberculosis lesions were detected by immunohistochemistry.Results:The
expressions of TNF-琢, IFN-酌, TGF-茁and IL-10 were different in tuberculosis (P<0.05); TNF-琢and IFN-r in proliferative lesions were
higher than those of the cheese necrotic lesions, while TGF-beta and IL-10 in cheese necrotic lesions were higher that those of the
proliferative lesions with statistically significant differences (P<0.05). There was no significant difference of TNF-alpha, TGF-beta and IL-10 in
the non-necrotizing granulomas and and necrotizing tuberculosis in the proliferative lesions (P>0.05); The expression of IFN- r in
necrotizing granulomas of tuberculosis was lower than that of the non-necrotizing (P<0.05). There was no significant difference of IFN-r
and IL-10 in necrosis and non-necrotizing granulomas of the cheese necrotic lesions, (P>0.05); The expression of TNF-alpha in the
non-necrotizing granulomas was higher than that of the necrosis (P<0.05).Conclusion:TGF-beta, TNF-alpha, IFN-r and IL-10 expressions play
the important role in the presence of bone and joint tuberculosis tissue for the occurrence and development of tuberculosis. |
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