| 刘明明 张晓艳 李炳蔚 王冰 刘淑英 盛有明 李宏伟 修瑞娟.激光多普勒对糖尿病小鼠微循环自律运动功能的评估[J].,2015,15(13):2408-2412 |
| 激光多普勒对糖尿病小鼠微循环自律运动功能的评估 |
| Evaluation of Microvascular Vasomotion in STZ-Induced Diabetic Mice byLaser Doppler |
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| DOI： |
| 中文关键词: 激光多普勒 微循环 糖尿病 |
| 英文关键词: Laser Doppler Microcirculation Diabetes |
| 基金项目:协和青年基金和中央高校基本科研业务费专项资金（33320140061) |
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| 中文摘要: |
| 目的：探讨激光多普勒对糖尿病小鼠微循环自律运动功能的评估价值。方法：20 只BALB/c 小鼠随机分为糖尿病组（n=10）
和对照组（n=10）。连续5 天腹腔注射40 mg/kg STZ诱导糖尿病模型；应用Moor LDLS检测糖尿病小鼠皮肤微循环血流灌注水
平；应用Moor VMS-LDF检测糖尿病小鼠胰腺微循环血流灌注及微血管自律运动功能。结果：糖尿病小鼠皮肤微循环血流灌注显
著降低，皮肤总血流灌注量（P=0.009）、胰腺微血管自律运动频率（P<0.001）和振幅（P<0.001）均显著低于对照组小鼠。结论：联合
应用Moor LDLS激光多普勒扫描成像系统及Moor VMS-LDF 激光多普勒血流灌注监测系统可作为糖尿病小鼠微循环功能状态
的评估手段。 |
| 英文摘要: |
| Objective:To evaluate the application of laser doppler in assessing microvascular vasomotion of STZ-induced diabetic
mice.Methods:20 BALB/c mice were randomly divided into diabetic group (n=10) and control group (n=10). Diabetic mice were induced
with 40 mg/kg STZ for 5 consecutive days. Cutaneous blood perfusion was determined by Moor LDLS, while pancreatic blood
perfusion and micro-vessels vasomotion were detected by Moor VMS.Results:Compared with control group, the cutaneous blood perfusion
and total flux (P=0.009) was decreased, and the frequency and amplitude of vasomotion of pancreatic micro-vessels was also decreased
in diabetic mice (P<0.001, P<0.001, respectively).Conclusion:Combined Moor LDLS and Moor VMS-LDF might be an applicable
method to evaluate microvascular vasomotion of diabetic mice. |
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