| 董先成 郎清 陈忠 蔡洪 赵龙.急性脑梗死患者介入治疗的疗效及对患者纤溶系统的影响[J].,2015,15(15):2900-2903 |
| 急性脑梗死患者介入治疗的疗效及对患者纤溶系统的影响 |
| Clinical Effect of Interventional Therapy on Acute Cerebral Infarction and itsImpact on the Fibrinolytic System |
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| DOI： |
| 中文关键词: 脑梗死 介入治疗 纤溶凝血系统 静脉溶栓 |
| 英文关键词: Cerebral infarction Interventional therapy Fibrinolysis coagulation system Intravenous thrombolysis |
| 基金项目: |
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| 中文摘要: |
| 目的：研究急性脑梗死患者脑血管球囊成形支架置入术治疗的临床疗效及其对患者纤溶系统的影响。方法：选择我院收治
的急性脑梗死患者68 例，随机分为观察1 组和观察2 组，各34 例，观察1 组给予尿激酶100 万U 静脉溶栓治疗；观察2 组给予
脑血管球囊成形支架置入术治疗，术后口服氯吡格雷和阿司匹林。观察两组患者治疗前、治疗后1d、7d 组织型纤溶酶原激活物
（tPA）、血浆血管性假血友病因子（vWF）、纤溶酶原激活物特异性抑制物（PAI-1）水平，并选择同期体检健康者30 例作为对照组。
结果：治疗后观察2 组血流再通明显高于观察1 组（P<0.05）；治疗前所有患者vWF、PAI-1、tPA 明显高于对照组，tPA/PAI-1 明显
低于对照组（P<0.05），但观察1 组和观察2 组比较无统计学差异（P>0.05）；治疗后1d观察1 组、观察2 组tPA、tPA/PAI-1 明显升
高，PAI-1 明显降低（P<0.05），治疗后7d，观察1 组tPA、tPA/PAI-1 明显降低，观察2 组vWF明显升高（P<0.05）。结论：脑血管球囊
成形支架置入术治疗急性脑梗死可使梗死的血管再次通畅，术后采用抗凝及抗血小板治疗，效果显著，且对体内纤溶系统无明显
影响，相比静脉溶栓治疗临床效果更加显著。 |
| 英文摘要: |
| Objective:To investige the clinical effect of cerebral vascular angioplasty and stenting in acute cerebral infarction and
its impact on the fibrinolytic system.Methods:68 patients of acute cerebral infarction in our hospital were randomly divided into observation
group 1 and observation group 2, each of 34 cases, observation group 1 were given 1 000 000 U of urokinase; observation group 2
group were given cerebral vascular angioplasty and stenting for the treatment of postoperative oral clopidogrel, aspirin. The plasma von
Willebrand factor (vWF), tissue type plasminogen activator (tPA), plasminogen activator inhibitor (PAI-1) level were detected before
treatment and 1 d, 7 d after the treatment.And selected 30 cases healthy persons as control group.Results:The reperfusion of observation
group 2 was significantly higher than that of observation group (P<0.05). Before treatment, the vWF, PAI-1, tPA of all patients were significantly
higher than those in control group, tPA/PAI-1 was significantly lower than that of the control group (P<0.05), but there was not
statistically significant between observation group 1 and 2(P>0.05). 1d after treatment, the tPA, tPA/PAI-1 increased in observation group
1 and 2 group, PAI-1 decreased significantly (P<0.05), 7d after treatment, the tPA, tPA/PAI-1 of observation group 1 decreased significantly,
the vWF of observation group 2 was significantly increased (P<0.05).Conclusion:Cerebral vascular angioplasty and stenting for
the treatment of acute cerebral infarction can make the reperfusion of infarct related artery and have little effect on fibrinolytic system,the
clinical effect is better than that of intravenous thrombolytic therapy. |
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