| 毛燕 陶磊 庞君 张国荣△.低压低氧对氧化- 抗氧化系统的影响[J].,2015,15(15):2981-2984 |
| 低压低氧对氧化- 抗氧化系统的影响 |
| Effect of Hypobaric Hypoxia on Oxidation, Antioxidant System |
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| DOI： |
| 中文关键词: 低压低氧 自由基 抗氧化系统 氧化应激 |
| 英文关键词: Hypobaric hypoxia Radicals Antioxidant system Oxidative stress |
| 基金项目:全军十二五重大项目（CKJ11J020） |
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| 中文摘要: |
| 低压低氧引起机体各组织器官的病理生理变化，其中氧化应激损伤是大多数疾病的病理生理基础。大量研究发现，低压低
氧导致机体内抗氧化酶水平降低，而脂质过氧化终产物丙二醛水平升高，表明低压低氧加重机体的氧化应激损伤。本文描述急性
低压低氧暴露以及间歇性低压低氧预处理对氧化- 抗氧化系统的影响，并阐述世居高原人群的高原适应性，就不同类型低压低氧
对机体氧化- 抗氧化系统的影响作一综述。急性低压低氧不仅影响抗氧化酶活性，而且具有抑制抗细胞凋亡蛋白，促进缺氧细胞
凋亡的作用，影响氧化- 抗氧化系统的平衡。而间歇性慢性低压低氧预处理则对组织器官具有保护作用，为治疗心血管疾病提供
了一条非药物治疗的可能途径。 |
| 英文摘要: |
| Hypobaric hypoxia causes pathophysiological changes on the tissues and organs, As a part of this, oxidative stress injury
is the pathophysiologic basis of most diseases. Numerous studies show that, hypobaric hypoxia results the reduction of antioxidant
enzymes levels in vivo, and oppositely increases the advanced lipoxidation end product malondialdehyde. These results demonstrate that
hypobaric hypoxia increases the oxidative stress injury. This article reviews the effect of different types of hypobaric hypoxia on oxidation,
antioxidant system. To Describe the effect of different types of hypobaric hypoxia on oxidation, antioxidant system, incluing the acute
hypobaric hypoxia、the chronic intermittent hypobaric hypoxia and the plateau adaptability. Acute hypobaric hypoxia affects not only the
activities of antioxidant enzymes, but also inhibits the anti-apoptotic protein by promoting the apoptosis of hypoxic cells. There is a significant
protective effect on tissues and organs after chronnic intermittent hypobaric hypoxia pretreatment. That may provide a non-drug
treatment for cardiovascular disease. |
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