| 陈伟伟 雷励党 惠娇 刘红 蔡少华△.慢性支气管炎患者下呼吸道感染病原菌分布及耐药性分析[J].,2015,15(19):3683-3685 |
| 慢性支气管炎患者下呼吸道感染病原菌分布及耐药性分析 |
| Study on the Distribution and Drug Resistance of Pathogenic Bacteria ofLower Respiratory Tract infection in Patients with Chronic Cronchitis |
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| DOI： |
| 中文关键词: 慢性支气管炎 下呼吸道感染 病原菌 耐药性 |
| 英文关键词: Chronic bronchitis Lower respiratory tract infection Pathogenic bacteria Drug resistance |
| 基金项目:国家自然科学基金项目（30901795） |
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| 中文摘要: |
| 目的：研究老年慢性支气管炎患者合并下呼吸道感染病原菌分布以及耐药性。方法：选取2009 年1 月到2013 年12 月我院
收治的老年慢性支气管炎患者合并下呼吸道感染患者261 例，采集所有患者的痰液，然后进行病原菌鉴定和药敏试验。结果：261
例患者中，144 例革兰阴性杆菌感染（55.2%），51 例革兰阳性杆菌感染（19.5%），66 例真菌感染（25.3%），其中混合感染者36 例
（13.8%）。革兰阴性杆菌以肺炎克雷伯菌最多（18.4%），革兰阳性杆菌以金黄色葡萄球菌最多（9.2%）。革兰阴性杆菌对亚胺培南的
耐药性最低，其次是头孢哌酮和阿米卡星，对氨苄西林耐药率最高。金黄色葡萄球菌和表皮葡萄球菌对青霉素的耐药率均为
100.0%，均对万古霉素敏感，其次是对环丙沙星敏感。结论：老年慢性支气管炎患者合并下呼吸道感染以革兰阴性杆菌感染为主，
真菌和混合感染也占一定的比例，应该引起注意。 |
| 英文摘要: |
| Objective:To study the distribution and drug resistance of pathogenic bacteria in elderly patients with chronic
bronchitis combined with lower respiratory tract infection.Methods:261 elderly patients with chronic bronchitis combined with lower
respiratory tract infection admitted in our hospital from January 2009 to December 2013 were enrolled in this study. The sputum of
patients were collected and conducted pathogen identification and drug sensitive test.Results:Among the 261 patients, 144 infected with
gramnegative bacilli which accounted for 55.2%, 51 infected with gram positive bacteria which accounted for 19.5%, 66 mainly infected
with fungus which accounted for 25.3%, and 36 were combined infection which accounted for 13.8%. The majority of gram negative
bacilli was klebsiella pneumonia which accounted for 18.4%, and the majority of gram positive bacteria was staphylococcus aureus
which accounted for 9.2%. The drug resistance of gram negative bacilli to Imipenem was the lowest, followed by Cefoperazone and
Amikacin, with the highest to Ampicillin. Staphylococcus aureus and staphylococcus epidermidis were 100.0%resistant to Penicillin, and
all sensitive to Vancomycin, followed by Ciprofloxacin.Conclusion:The majority of lower respiratory tract infection in elderly patients
with chronic bronchitis was gram negative bacilli, and there were also certain percentages of fungus and combined infection, which
should be paid attention to. |
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