| 刘佳 钟成福 张勇 刘旭阳 贾宁 李凡.雌激素与丹栀逍遥丸对更年期女性生殖内分泌系统及免疫功能的调节作用[J].,2015,15(19):3728-3730 |
| 雌激素与丹栀逍遥丸对更年期女性生殖内分泌系统及免疫功能的调节作用 |
| Regulation of Estrogen Combined with Danzhi XiaoyaoCapsule on the Reproductive Endocrine and ImmuneFunction of female patients with Climacteric Cyndrome |
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| DOI： |
| 中文关键词: 雌激素 丹栀逍遥胶囊 更年期综合征 内分泌激素 免疫功能 |
| 英文关键词: Estrogen Dangzixiaoyao capsules Climacteric syndrome Endocrine hormone Immune function |
| 基金项目:国家自然科学基金项目（81173190） |
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| 中文摘要: |
| 目的：探究雌激素联合丹栀逍遥胶囊对更年期综合征妇女生殖内分泌系统及免疫功能的调节作用。方法：选取2014 年5月
至2014 年9 月我院收治的女性更年期综合症患者60例并将其随机分为两组，其中对照组给予雌激素替代等临床常规疗法；实
验组在雌激素替代治疗基础上加用丹栀逍遥胶囊联合治疗。观察并比较两组患者生殖内分泌激素(E2、FSH、LH)水平、T 淋巴细胞
亚群(CD3＋、CD4＋、CD8＋、CD4＋/CD8＋)比例以及IL-2 活性的变化。结果：治疗后，两组血清E2、CD3＋、CD4＋、CD4＋/CD8＋水平及IL-2 活
性均较治疗前显著升高，而FSH、LH 水平均明显低于治疗前，且实验组治疗后E2、CD3＋、CD4＋、CD4＋/CD8＋水平及IL-2 活性显著高
于对照组，FSH、LH 水平均明显低于对照组，差异均有统计学意义(P<0.05)。结论：雌激素联合丹栀逍遥胶囊能更加有效调节女性
更年期综合征患者生殖内分泌激素水平，提高免疫功能，值得临床推广。 |
| 英文摘要: |
| Objective:To explore the regulatory effect of estrogen combined with Danzhi Xiaoyao Capsule on the reproductive
endocrine and immune function of female patients with climacteric syndrome.Methods:60 female patients with climacteric syndrome
admitted in our hospital from May 2014 to September 2014 were selected and randomly divided into two groups, 30 patients in the
control group were treated by the clinical?routine of estrogen replacement, while the other 30 patients in the observation group were
treated by dang zi xiao yao capsules based on the use of estrogen replacement therapy. After treatment, the reproductive endocrine
hormone(E2, FSH, LH) levels, the ratio of T lymphocyte subsets(CD3+, CD4+, CD8+, CD4+/CD8+), the changes of IL-2 activity were observed
and compared between two groups.Results:After treatment, the E2, CD3＋, CD4＋, CD4＋/CD8＋ levels and IL-2 activity of both groups were
significantly higher than those before treatment (P<0.05), while the FSH, LH levels were obviously lower (P<0.05). Moreover, the E2,
CD3＋ , CD4＋ , CD4＋/CD8＋ levels and IL-2 activity of expreriment group after treatment were all significantly higher than those of the
control group(P<0.05), while the FSH, LH levels were obviously lower(P<0.05).Conclusion:Estrogen combined with Danzhi Xiaoyao
capsule could effectively regulate the reproductive endocrine hormone levels and improve the immune function of female patients with
climacteric syndrome, which was worthy of clinical application. |
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